Influence of green synthesized (Rutin) copper oxide nanoparticles impregnated scaffold on the expression of osteocalcin and type 1 collagen
DOI:
https://doi.org/10.48047/vkctt745Keywords:
Bone tissue engineering, Nanoparticles, Copper oxide, Scaffolds, Osteogenesis, RegenerationAbstract
Background: Bone tissue engineering aims to regenerate bone defects using biocompatible materials and bioactive agents. Nanoparticles offer significant advantages by enhancing cell material interactions, delivering therapeutic molecules, and modulating biological responses.
Methods: In this study, scaffolds were fabricated using a blend of hyaluronic acid, carrageenan, and gelatin. Rutin-doped copper oxide nanoparticles were incorporated into the scaffold matrix. The osteogenic potential of these scaffolds was evaluated by assessing cell proliferation, differentiation, and gene expression of osteogenic markers (osteocalcin and collagen type I).
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References
Patel JK, Pathak YV. Emerging Technologies for Nanoparticle Manufacturing. Springer Nature; 2021.
Grodetskaya TA, Evlakov PM, Fedorova OA, Mikhin VI, Zakharova OV, Kolesnikov EA, et al. Influence of Copper Oxide Nanoparticles on Gene Expression of Birch Clones In Vitro under Stress Caused by Phytopathogens. Nanomaterials (Basel) [Internet] 2022;12.
Available from: http://dx.doi.org/10.3390/nano12050864
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