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Albumin-to-Fibrinogen Ratio as a Prognostic Biomarker in Acute Myeloid Leukemia
Background: Acute myeloid leukemia (AML) is a heterogeneous hematologic malignancy characterized by clonal proliferation of myeloid precursor cells in the bone marrow and peripheral blood. Despite advances in molecular diagnostics and risk-adapted therapies, prognosis remains poor for many patients, and accurate prognostic biomarkers are essential for improving risk stratification
Albumin-to-fibrinogen ratio; Acute myeloid leukemia; Prognostic biomarker
Ayman Fathy Abd El-halim , Heba Allah Elsayed Mohammed Abdelrhman , Ahmed Mahmoud Ali Ahmed , Elsayed Anany Metwally Mohamed
Copyright (c) 2026 https://creativecommons.org/licenses/by/4.0/deed.en
Inflammation and Tumor Biomarkers in HCC Immunotherapy: The Emerging Role of C Reactive Protein and Alpha-Fetoprotein
Background: Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related mortality worldwide, with its incidence driven by chronic liver diseases such as viral hepatitis, alcohol-related liver disease, and metabolic dysfunction–associated steatotic liver disease. Despite advances in surveillance and treatment
HCC Immunotherapy, C-Reactive Protein ,Alpha-Fetoprotein
Mohamed Ali Elsayed , Mostafa H. Elshamy , Amrallah A. Mohamed , Mostafa Moaz , Ahmed M. El-Gebaly
Relation Between Toxic Leadership and Job Embeddedness
Background: Toxic leadership is defined as a persistent pattern of destructive behaviors by individuals in leadership positions that harm employees and organizational culture. In nursing, toxic leadership undermines morale, increases stress and contributes to burnout and turnover. It is characterized by manipulation, hostility and disregard for staff well-being, making it a serious threat to healthcarequality and safety. Aim: To investigate relation between nurse managers’ toxic leadership behaviors and Job Embeddedness.
toxic Leadership, Nurses, Job Embeddedness
Raghda Salah Mohamed , Magda AtiyaGaber , Aisha El-Sayed El-Araby
Predicting Preeclampsia Using Placental Laterality and Uterine Artery Doppler: Clinical Performance, Pitfalls, and Imaging Protocols
Background: Preeclampsia remains one of the leading causes of maternal and perinatal morbidity and mortality worldwide. Despite advances in obstetric care, early identification of women at increased risk continues to be a clinical challenge. Abnormal placentation and impaired spiral artery remodeling are central to the pathophysiology of preeclampsia and precede the onset of clinical disease by several weeks to months. Ultrasound-based markers, particularly placental location and uterine artery D
Placental Location, Uterine Artery Doppler, Preeclampsia
Helmy Ismail Abdel Samad Ismail, Taghreed Mohamad Azmy, Ahmed Abdel Aziz El Sammak, Ghada Adel AbdelHamid
Enhancing Innovative Work Behavior in Nursing through Job Crafting Intervention
Background: Job crafting facilitates change and motivates the nurse to find novel means of performing tasks. Changing work methods increases involvement and decreases the level of boredom, frustration, and emotional exhaustion. Therefore, nurses feel enthusiastic and energetic, which stimulates the creation of new ideas
Job Crafting; Innovative Work Behavior; Intervention Program; Nurses.
Ehsan Hussein Gouda Magda Atiya Gaber Wafaa Mostafa Mohamed Aisha El-Sayed El Araby
Acute Non-Cardioembolic Ischemic Stroke: Dual Antiplatelets for Secondary Prevention— Clinical Profile, Timing, Duration, and Outcomes
Background: Acute non-cardioembolic ischemic stroke accounts for the majority of ischemic cerebrovascular events and remains a leading cause of long-term disability and mortality worldwide. Early secondary prevention is crucial, as the risk of recurrent ischemic stroke is highest within the first days to weeks following the index event. Antiplatelet therapy represents the cornerstone of management in this population, with aspirin traditionally used as monotherapy. However, residual early recurrence despite single antiplatelet therapy has prompted growing interest in dual antiplatelet therapy (DAPT) as a more effective short-term strategy to reduce ischemic events.
Acute Non-Cardioembolic Ischemic Stroke, Dual Antiplatelets, Outcomes
El-Hady Ahmed Abd El Gawwad, Tarek Abd El Rahman Goda, Eman Mohamed Elewa Mansour, Nancy Abd El Hameed Mohamed
Cemented Bipolar Hemiarthroplasty for Femoral Neck Fractures in Osteoporotic Patients: An Evidence-Based Review
Background: Femoral neck fractures represent a major public health concern, particularly among elderly osteoporotic patients, due to their association with high morbidity, mortality, and socioeconomic burden. Osteoporosis compromises bone quality, making internal fixation unreliable and increasing the risk of fixation failure, nonunion, and reoperation. Arthroplasty has therefore become the preferred treatment for displaced femoral neck fractures in this population. Among available options
Cemented Bipolar Hemiarthroplasty, Femoral Neck Fractures, Osteoporotic Patients
Adel Mohamed Salama, Mohamed Khaled Saleh, Gehad Mohamed Ali, Ahmed Hassan Zaki
Elafin in Behçet’s Disease: A Potential Link Between Neutrophilic Inflammation and Disease Activity
Background: Behçet’s disease (BD) is a chronic, relapsing, multisystem inflammatory disorder characterized by recurrent mucocutaneous lesions, ocular involvement, and systemic manifestations, with a pathogenesis strongly driven by neutrophilic hyperactivity and dysregulated innate immunity. Among emerging biomarkers reflecting neutrophil-mediated inflammation,
Elafin ,Behçet’s Disease, Disease Activity
Lobna. I. Kotb , Dalia Samir Fahmi, Leila Elsayed Ismail , Marwa Abo Shabana
Efficacy of Probiotics in Reducing Pathological Jaundice in Neonates: An Evidence-Based Review of Preterm and Full-Term Neonates
Background: Neonatal jaundice is one of the most common clinical conditions encountered in both preterm and full-term Neonates, with pathological hyperbilirubinemia posing significant risks for bilirubin-induced neurologic dysfunction, including acute bilirubin encephalopathy and kernicterus
Probiotics , Pathological Jaundice ,Neonates: Preterm, Full-Term Neonates
Abdelrazek Elsheikh , Maha Abdelaziz Nouh , Amira Raafat , Samaa Mohammed Abdel Moneim JCDR
Closed Reduction of Nasal Fractures: Outcomes, Pitfalls, and Contemporary Controversies
Background: Nasal fractures represent the most common type of facial fracture, accounting for a substantial proportion of emergency and outpatient otolaryngologic and plastic surgery consultations. Despite their frequency, optimal management remains a subject of ongoing debate, particularly regarding the role and effectiveness of closed reduction.
Closed Reduction, Nasal Fractures, Controversies
Fady Ghaly Shafik, Mohamed Ali Mostafa Nasr , Hisham Abo-alez Ibrahim
Coronal and Sagittal Plane Malalignment in Anterior Cruciate Ligament Deficiency: Clinical Implications, and Surgical Strategies
Background: Anterior cruciate ligament (ACL) deficiency is a complex pathological condition that extends beyond isolated ligament disruption, involving significant alterations in knee biomechanics influenced by both coronal and sagittal plane malalignment. Increasing evidence suggests that factors such as varus deformity and increased posterior tibial slope (PTS) play a pivotal role in the pathogenesis of ACL injury, persistence of instability, and failure of reconstruction. Despite advances in surgical techniques, failure rates followingACL reconstruction (ACLR) remain notable, highlighting the importance of addressing underlying osseous malalignment.
Coronal,Sagittal Plane Malalignment, Anterior Cruciate Ligament Deficiency
Eslam Nagy Hadhoud , Khalid Mohamed Hassan, Mohamed AbdAlla M. Abdelsalam, Mohamed Attia Abdelmoeti
Contemporary Management of Giant Cell Tumor of the Distal Femur: Role of Extended Curettage and Bone Cement Reconstruction
Background: Giant cell tumor of bone (GCTB) is a locally aggressive, osteolytic neoplasm that typically affects skeletally mature individuals, with a predilection for the epimetaphyseal region of long bones. The distal femur represents one of the most commonly involved sites and poses unique challenges due to its proximity to the knee joint, high functional demands, and risk of local recurrence. Historically, wide resection was advocated to minimize recurrence; however, this approach often compromises joint integrity and functionaloutcomes. Advances in surgical techniques and local adjuvant therapies have led to a paradigm shift toward limb- and joint-preserving strategies.
Giant Cell Tumor, Distal Femur, Extended Curettage and Bone Cement Reconstruction
Omar Mohamed Abdel-Wahab Kelany , Reda Hussein El-Kady , Shreef Ehab Mohamed Sedky Rohoma, Mohamed Hassan Abd ellatief
Working Conditions, Illnesses, and Accidents Among Brick Kiln Workers
Background: Brick kiln workers are exposed to demanding working conditions that may negatively affect their health and increase the risk of work-related accidents and illnesses. Long working hours, lack of employment security, limited social protection, and unsafe work environments are common features of brick kiln work. Therefore, this study aimed to assess working conditions, work-related accidents, and work-related illnesses among brick kiln workers
Brick kiln workers, working conditions, work-related accidents, work-related illnesses, and occupational health and safety.
Eman Al-Abed Mohammed Ibrahim, Esraa Mohammed Abd El-Aziz Al Hanbaly, Nashwa Saber Elsayed Atia, and Salwa Abbas Ali Hassan
Digital Breast Tomosynthesis in the Evaluation of Mammographically Indeterminate Breast Lesions: A Comprehensive Review
Background: Digital Breast Tomosynthesis (DBT) has emerged as one of the most impactful technological advancements in breast imaging, particularly for the evaluation of mammographically indeterminate lesions. Conventional 2D digital mammography (DM) remains the cornerstone of breast cancer screening, yet its inherent limitation—tissue overlap—often results in false-positive recalls, ambiguous findings, and missed malignancies. DBT addresses this challenge by generating quasi-three-dimensional reconstructions that allow radiologists
Digital Breast Tomosynthesis, Mammography, Breast Lesions
Mohamad Hamid Abowarda, Sameh Sabr Bayoumi, Samar Sayed Omran, Mona Mohammed Refaat
Computation analysis to identify hsa-microRNA-1225-5p from the head and neck squamous cell carcinoma (HNSCC) human genome sequence.
Background: Head and neck squamous cell carcinoma (HNSCC) is the eighth most frequent cancer in people worldwide. Finding HNSCC biomarkers is crucial for enhancing patient care by enabling earlier patient diagnosis and treatment. Interestingly, microRNAs (miRNAs or miRs) are studied for their potential role as biomarkers and therapeutic targets in various diseases, including OSCC
Head and neck squamous cell carcinoma; microRNAs; biomarkers; therapeutic target; hsa-miR-1225-5p
Gayathrie, Dhanraj M Ganapathy, Durairaj Sekar
MACHINE LEARNING PREDICTION OF PULPECTOMY FURCATION LESIONS USING RADIOGRAPHIC IMAGES
Pulpectomy is a common endodontic procedure in pediatric dentistry aimed at preserving primary teeth affected by pulpal pathology. One of the significant complications associated with pulpectomy-treated teeth is the development of furcation lesions, which occur due to the anatomical characteristics of primary molars, including accessory canals in the furcation region. Early and accurate detection of these lesions is essential to prevent treatment failure and ensure proper oral health outcomes.
ADME Profiling and In Silico Evaluation of Embelia ribes Phytochemicals as Human Lysyl Oxidase-Like 2 (hLOXL2) Inhibitors
Cancer and fibrotic disorders remain major global health challenges, prompting the search for novel therapeutic targets and safer drug candidates. Among the molecular targets implicated in disease progression, Lysyl Oxidase‑Like 2 (LOXL2) has emerged as an important enzyme involved in extracellular matrix remodeling and collagen cross-linking
Toxicity Profiling and In Silico Evaluation of Embelia ribes Phytochemicals as Human Lysyl Oxidase-Like 2 (hLOXL2) Inhibitors
Human lysyl oxidase-like 2 (hLOXL2) is a copper-dependent enzyme that catalyzes oxidative deamination of lysine residues inextracellular matrix (ECM) proteins. Dysregulated LOXL2 activity is linked with pathological fibrosis, tumor progression and metastasis, and abnormal tissue remodeling.
A CBCT study of root canal morphology of bilateral maxillary premolars in South Indian population
Background:The objective of this study was to use CBCT to look into the root canal morphology of bilateral maxillary premolars in a South Indian population and associate the results to existing canal morphology classifications.
Cone beam computed tomography, Canal morphology, Maxillary premolars, South Indian population
Evaluation of different types of isolation techniques in dentistry - Overview
Background: In dentistry, it is well known that the main cause of procedure failure is inadequate tooth isolation. Even though it’s been a staple of modern dentistry for decades, isolation remains a pesky but critical step particularly in endodontic and restorative procedures. It’s not just one aspect of isolation that makes it difficult but tooth isolation by nature isn’t easy, specifically when you add in the patient’s comfort, it can be a challenging task. Any operative procedure needs adequate space over the operating field. There must be proper control of moisture, good accessibility and visibility as well as spacious for instrumentation around the working area. For easy manipulation this kind of environment is necessary. The aim of this review is to evaluate the different types of isolation techniques in dentistry.
Cotton roll; Isolation; Isolite; Operating field; Rubber Dam
Priyanka Sivasubramanian, Dr. Rajasekar G
Evaluation of pain while giving local anaesthesia for extraction using single use syringe vs insulin syringe
Background: The evaluation of pain during local anesthesia administration for dental extractions is crucial for improving patient comfort and procedural outcomes. Traditional single-use dental syringes are commonly used for this purpose, but recent studies suggest that insulin syringes, with their finer gauge needles, may offer less discomfort. This study aims to compare pain perception between single-use dental syringes and insulin syringes during mandibular nerve block procedures to determine which method provides a more comfortable experience for patients.
Insulin syringe, local anaesthesia, nerve block, extraction.
Priyanka Sivasubramanian , Dr. Soya Alfred
Comparative evaluation of flexural strength of type II type VII and nano based glass ionomer cement - In vitro
Introduction:- The capacity of a material to withstand bending forces applied perpendicular to its longitudinal axis is known as flexural strength. It is a phrase that is frequently used in dentistry. Megapascals, or MPa, are the metric units used to describe it. Glass ionomer cements (GICs) are aesthetically pleasing dental products with special qualities that make them effective as luting and restorative materials. GIC cements come in a total of 9 varieties
Flexural strength; Type 2 GIC; Type 7 GIC; Titanium; Dip coating.
Priyanka Sivasubramanian , Dr.K.Vaishnavi, Balaji Ganesh. S, S.Jayalakshmi
Prevention and Treatment of Vasospasm in Microvascular Anastomosis: Evidence from Rat Model Studies
Background: Vasospasm remains a significant intraoperative challenge in microvascular surgery and may compromise the success of microvascular anastomosis during reconstructive procedures. The phenomenon is characterized by a transient but often severe constriction of the vessel wall, leading to reduced blood flow and potential thrombosis. In microsurgical free tissue transfer, even minor reductionsin arterial inflow or venous outflow may threaten flap viability
Vasospasm ,Microvascular Anastomosis, Rat Model Studies
Mohammed Salah Awad, Mohamed Hamed Abdel-Raheem, Mohammed Adel Saqr, Ahmed Mohammed Ibrahim Moustafa Allam
Risk-Score–Based Diagnosis of SBP in Cirrhosis: Mansoura Scoring System Versus Absolute Neutrophil Count
Background: Spontaneous bacterial peritonitis (SBP) remains a frequent and life-threatening complication of liver cirrhosis, contributing substantially to morbidity, mortality, and health care utilization. Early diagnosis is critical, as prompt initiation of empirical antibiotics significantly improves outcomes. For decades, the diagnosis of SBP has relied primarily on an ascitic fluid polymorphonuclear neutrophil
SBP, Cirrhosis, Mansoura Scoring System , Absolute Neutrophil Count
Abdalla Moatasem Nawara , Mohamed Ali Mohamed Ahmed , Heba Shafeak Abd El Khalik
Influence of Early Postmortem Interval on the Detection of Hepatic Diazepam Concentrations in Male Albino Rats
Background: Background: The increasing misuse of benzodiazepines (BZDs) in drug-facilitated crimes (DFCs) has become a serious concern for forensic experts, healthcare professionals, and legal authorities. These drugs, which are commonly prescribed for anxiety and sleep disorders, are also used to commit crimes such as sexual assault and robbery. Their sedative and memory-blocking effects render them particularly dangerous. So, the aim of the present work is to study the effect of postmortem interval on diazepam concentration inliver tissue after acute oral lethal dose administration in male albino rats, using Gas Chromatography- Mass Spectrometry (GC-MS)
postmortem interval, forensic toxicology, diazepam, GC-MS.
Sally Usama Elsaid Ibrahim , Nermien Attia Abd Moneim Ibrahim, Marwa Tawfik Abd El Hamide Abaza, Ghadeer Mohamed Mahmoud Abdelaal
Cytokine Signaling Dysregulation and Pruritus in Cutaneous T-Cell Lymphoma: Emerging Molecular Insights and Clinical Correlations
Background: Cutaneous T-cell lymphoma (CTCL), particularly Mycosis Fungoides, represents a heterogeneous group of non-Hodgkin lymphomas characterized by malignant proliferation of skin-homing T lymphocytes and a chronic, often indolent clinical course. Among its most debilitating and frequently reported symptoms is pruritus, which significantly impairs quality of life and often correlates withdisease progression. Despite its clinical importance, the molecular mechanisms underlying pruritus
Cytokine Signaling, Pruritus, Cutaneous T-Cell Lymphoma
Manal Mohamed El-Sayed , Rania Abdelaziz Alakad , Hayam Elsayed Hassan Rashed , Amina Ahmed Mohamed Abdelhadi , Afnan Samy Ali Hussein Aziza
Bronchiolitis in the First Year of Life: Evidence-Based Clinical Assessment and Risk Stratification in Primary Care
Background: Bronchiolitis is the most common lower respiratory tract infection in infants during the first year of life and represents a leading cause of primary care consultations, emergency department visits, and hospitalization worldwide. Respiratory syncytial virus (RSV) remains the predominant etiologic agent, although other viral pathogens contribute significantly. Despite its high prevalence
Bronchiolitis, First Year of Life, Infants
Nora Nabil Hussien, Soad A Shedeed , Noura Hassan Soultan, Nahla Ashraf Zaitoun
PREVALENCE, RISK FACTORS, AND OCCUPATIONAL IMPACT OF MUSCULOSKELETAL DISORDERS AMONG ORTHOPEDIC TRAUMA SURGEONS: A CROSS-SECTIONAL SURVEY STUDY
Surgeon injury and hazards have now become more of an issue primarily in orthopedic surgery. The reason as to why this research was done was to determine how prevalent orthopedic trauma surgeons are musculoskeletally injured and the type of injury they sustain, and whether the injury has any discernable effect on their career. A survey with a different degree of minor modification of the initial one (a physical discomfort survey) was sent to the members of the Orthopaedic Trauma Association (OTA), where 100 respondents were surgeons. The majority of the sampled were male (85%), and their right hand is the most frequently used (92%), and their greatest source of work was academic centers. The majority of the respondents (63%) stated that they were injured at work and the most prevalent was the low back pain. Surgeons above 45 years reported an increase in the cases of injury (75%), whereas the cases among younger surgeons were nearly 20% lesser (54.5%). Women operating were identified to get injured much more frequently than their male counterparts (84.6% vs. 61. 6) and the same was the case with right-handed surgeons who depicted a high number of injuries compared with the left-handers. The highest rate of injury was experienced by community surgeons and surgeons who practiced in more than one facility (76.1 and 80 percent respectively). Surgeons who handled injuries were forced to miss work as much as 27 percent of their workweek, those over 65 and those working in more than one institution (academic and private practice) had the highest number of missed work weeks. The correlation between the frequency of injuries in patients and the number of surgeries performed by a physician per year was not strong. Surgeons with a period of use exceeding ten years tended to have more than one of their body parts injured. These are the fact that in many instances they are required to deal with challenging, demanding and risky cases. They state that the operating room should be fitted with better ergonomic measures like body supports, taking frequent stretching breaks, use of microscopes to ensure good body position and use of power assisted tools to reduce the body strain. In case the ergonomics of the working environment is enhanced, the number of surgeons who develop musculoskeletal disorders might decrease and this will probably be beneficial to the wellbeing of the surgeons, the potential of the working population and patient care.
Copyright (c) 2024 Dr. Ashok Reddy, Dr. Danduru Vasudevava Reddy (Author) https://creativecommons.org/licenses/by/4.0/deed.en
THE EFFICACY AND SAFETY OF LEBRIKIZUMAB PLUS TOPICAL CORTICOSTEDOIDS IN MODERATETO SEVERE ATOPIC DERMATITIS.
Inflammatory and chronic skin conditions such as AD have a serious impact on patients' quality of life. A phase 3 randomised, placebo-controlled trial, ADhere (NCT04250337) examined the efficacy and safety of low-to-mid potency topical corticosteroids (TCSs) that contain IL-13 monoclonal antibody in moderate and severe AD, adolescents, and adults. Combining lebrikizumab and TCS was found to have tremendous effects on skin clearance and itch intensity, sleep disturbances, and quality of life in the trial. There has already been a statistically significant increase in EASI-75 week 4 and IGA (0,1) week 8 responses. Combination therapy was highly compliant and mild or moderate adverse events were reported mainly. In addition, these findings support the use of lebrikizumab and TCS as an effective method of managing moderate and severe AD.
Copyright (c) 2024 https://creativecommons.org/licenses/by/4.0/deed.en
Can Targeting Oxidative Stress and Inflammation with Lycopene Prevent Paclitaxel-Induced Spermatogenic Disruption?
Background: Paclitaxel is a widely used chemotherapeutic agent effective against various solid malignancies, including breast, ovarian, and lung cancers. Despite its therapeutic efficacy, accumulating experimental and clinical evidence indicates that paclitaxel exerts deleterious effects on the male reproductive system. Testicular tissue, characterized by rapid germ cell proliferation and high polyunsaturated fatty acid content, is particularly vulnerable to chemotherapeutic-induced
Paclitaxel; Lycopene; Testicular toxicity; Oxidative stress; Inflammation; Spermatogenesis; Reactive oxygen species; Chemotherapy-induced gonadotoxicity; Antioxidants; NF-κB.