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Revisiting the Hypothalamic–Pituitary–Gonadal Axis in β-Thalassemia: Is Kisspeptin the Next-Generation Diagnostic Tool?
Background: Delayed puberty is one of the most prevalent endocrine complications in adolescents with β-thalassemia major, primarily resulting from iron overload–induced dysfunction of the hypothalamic–pituitary–gonadal (HPG) axis. Despite advances in transfusion protocols and iron chelation therapy, hypogonadotropic
b-thalassemia major; delayed puberty; hypogonadotropic hypogonadism; kisspeptin; gonadotropin-releasing hormone; HPG axis; iron overload; pediatric endocrinology; dynamic testing; neuroendocrine dysfunction
Laila M Sherief1, Mervat Atfy , Ihab Abdelhameed, Doaa Metwaly , Esraa Hassan Ibrahim Elsayed
Copyright (c) 2026 https://creativecommons.org/licenses/by/4.0/deed.en
THE INFLUENCE OF FOOD SECURITY ON THE PREVALENCE OF MALNUTRITION AND ANAEMIA IN CHILDREN AGED 5-12: A CROSS-SECTIONAL STUDY
Introduction: Malnutrition and anaemia remain intertwined public health challenges among school-age children in Tamil Nadu. Tiruvallur district, located on the north-western periphery of Chennai, is characterised by semi-urban slums, migrant labour communities, and fragile agrarian livelihoods that collectively compromise household food security. Despite measurable economic growth in the region, childhood malnutrition and iron-deficiency anaemia persist at levels above the state average, demanding systematic elucidation of their socio-economic and dietary determinants. Materials and Methods: A mixed-method cross-sectional study was conducted at Indira Medical College and Hospital, Tiruvallur. Both probability (simple random and systematic) and purposive sampling were employed. The study population comprised 120 school-age children aged 5–12 years attending the paediatric outpatient department and their caregivers (n = 110). Anthropometric indices (height-for-age, weight-for-age, BMI-for-age) were assessed using WHO (2007) reference standards. Haemoglobin was measured by cyanmethaemoglobin method; anaemia was defined per WHO (2011) criteria. Statistical comparisons were performed by one-way ANOVA followed by Tukey-Kramer post hoc test (GraphPad InStat v5, P < 0.05). Results: Children aged 5–8 years constituted 52% of the malnourished group; males were disproportionately affected (55% vs 45%). Low birth-weight children (≤2.4 kg) formed 61% of the malnourished sample, 17 times more prevalent than those born above 3.1 kg (P < 0.001). Twice-daily meals were the dominant feeding pattern in 59% of children and 54% of adults. Anaemia was detected in 68% of malnourished children; 42% had moderate anaemia (Hb 7.0–9.9 g/dL). Households earning below ₹3,000/month represented 71% of the sample. Fathers were the sole income decision-makers in 46% of households with malnourished children (P < 0.001). Low food consumption scores (0–21) were present in 62% of households. Conclusion: Malnutrition and anaemia in school-age children in Tiruvallur are strongly determined by low household income, paternal decision-making dominance, low birth weight, restricted meal frequency, and limited dietary diversity. Targeted nutritional interventions integrating iron supplementation, school meal programmes, and caregiver education are urgently warranted.
Inflammatory Burden and Early Outcomes after Primary PCI: Pathophysiological Insights and Prognostic Implication
Background: Acute ST-segment elevation myocardial infarction (STEMI) remains a leading cause of morbidity and mortality worldwide despite significant advances in reperfusion strategies, particularly primary percutaneous coronary intervention (PCI). Beyond epicardial coronary artery occlusion, the inflammatory response triggered by plaque rupture and myocardial ischemia plays
Ragab Abdel Salam Mahfouz, Mohammad Gouda Mohammad , Islam Mohamed Ali Elhorbity, Mohamed Salah Abdelbasit
COMPARATIVE EVALUATION OF SURFACE ROUGHNESS OF FLOWABLE COMPOSITE RESIN AFTER BRUSHING SIMULATION WITH FLUORIDATED AND REMINERALISING TOOTHPASTE - AN IN VITRO STUDY
Introduction: Composite resin is the material of choice for anterior tooth restorations in adult and pediatric patients. Surface roughness is a crucial property in the success of dental restoration.Toothbrushing may influence the wear and surface roughness
composite resin, surface roughness, brushing simulator, stylus profilometer, innovative measurement
Thiru Kumaran V, Balaji Ganesh S, Jayalakshmi S
IDENTIFICATION OF NOVEL TL 15 PEPTIDE TARGET IN PORPHYROMONAS GINGIVITIS AND PROPOSING INHIBITOR AGAINST HEME-BINDING
This study focuses on the identification of a novel TL 15 peptide target in Porphyromonas gingivalis, exploring its potential as a therapeutic target against heme-binding. The aim is to propose an inhibitor that could disrupt this interaction
ANTIMICROBIAL EFFICACY OF FLUORIDE RELEASING FISSURE SEALANTS- IN-VITRO STUDY
This in-vitro study delves into the critical realm of antimicrobial efficacy, focusing specifically on fluoride-releasing fissure sealants. Through meticulous examination and analysis, we aim to unravel the effectiveness of these sealants in combating microbial activity
MACHINE LEARNING PREDICTION OF ENDO-PERIO LESIONS USING RADIOGRAPHIC IMAGE
The introduction to a machine learning prediction study on endo-perio lesions using radiographic images should outline the significance of the problem, current challenges in diagnosis, and the potential impact of predictive models
Immunotherapy in Non–Small Cell Lung Cancer: Mechanisms, Biomarkers, Clinical Outcomes, and Future Directions
Background: Immunotherapy has transformed the therapeutic landscape of non–small cell lung cancer (NSCLC), redefining standards of care across metastatic, locally advanced, and early-stage disease. Historically associated with poor survival outcomes, advanced NSCLC management was dominated by platinum-based chemotherapy
Immunotherapy, Non–Small Cell Lung Cancer, Future Directions
Ahmed Ali Obaya , Lobna Abdelaziz Abdelaziz , Manar Mahmoud Mohammed Yousof , Basant Sh Elshafaay
Physiological Basis of Cardiovascular Protection by SGLT2 Inhibitors in Diabetic Ischemic Heart Disease
Background: Diabetes mellitus is a major global health problem and represents a leading contributor to cardiovascular morbidity and mortality. Among the various cardiovascular complications associated with diabetes, ischemic heart disease remains the most prevalent and life-threatening condition. Chronic hyperglycemia
Cardiovascular Protection, SGLT2 Inhibitors, Diabetic Ischemic Heart Disease
Nadine Ahmed Raafat, Reham Hassan El-Azoney, Sara Tarek Mohammed El-Esawey, Sara G. Seada
Quadriceps Tendon Sling Versus Semitendinosus Autograft for Medial Patellofemoral Ligament Reconstruction: Review of Biomechanics, Surgical Techniques, Outcomes
Background: Recurrent patellar instability is a common orthopedic condition, particularly among young and physically active individuals, and it is frequently associated with injury or insufficiency of the medial patellofemoral ligament (MPFL). The MPFL functions as the primary passive stabilizer of the patella against lateral displacement,
Quadriceps Tendon Sling, Semitendinosus Autograft, Medial Patellofemoral Ligament Reconstruction
Mohamed Abdallah ElSofy, Mohamed Hamed Fahmy, Mohamed Saeed ElAttar, Mohamed Akmal Diab
Fatty Acid Binding Protein 4 (FABP 4) in Osteoarthritis: Linking Metabolic Inflammation to Joint Degeneration
Background: Osteoarthritis (OA) is a highly prevalent chronic joint disorder and a leading cause of pain, disability, and reduced quality of life. While traditionally viewed as a “wear-and-tear” condition, OA is now recognized as a whole-joint disease driven by biomechanical overload and low-grade inflammation, with a distinct metabolic
Maha Taha Abdel-Halim Taha, Abeer Mohamed El-Shafey, Nahla Ibrahim Zidan , Dalia Ibrahim Ahmed Mostafa
Microneedling with Hyaluronic Acid for Acne Scars: Factors Influencing Therapeutic Outcomes
Background: Acne scarring represents a frequent and distressing complication of acne vulgaris, often leading to significant psychosocial burden and reduced quality of life. Atrophic acne scars, including ice-pick, boxcar, and rolling scars, arise from dermal matrix destruction and abnormal wound healing following inflammatory acne lesions. Various therapeutic modalities have been developed to improve scar appearance, including chemical peels, laser resurfacing, subcision, dermal fillers, and microneedling. Among these, microneedling has gained substantial attention due to its minimally invasive nature, favorable safety profile, and effectiveness across different skin phototypes. In recent years, the combination of microneedling with topical or transdermal delivery of hyaluronic acid has emerged as a promising strategy to enhance clinical outcomes in acne scar management.
Acne scars; Microneedling; Hyaluronic acid; Atrophic acne scars; Percutaneous collagen induction; Transdermal drug delivery; Dermal remodeling; Skin rejuvenation; Scar treatment outcomes; Predictors of therapeutic response.
Ayman youssef, Marena Yousry Haliem Kamel , Rana Ahmed
Preseptal Transconjunctival Approach for Orbital Floor Fracture Reconstruction: Surgical Anatomy, Technical Considerations, and Clinical Outcomes
Background: Orbital floor fractures represent a common subset of midfacial trauma and frequently result from blunt force mechanisms such as interpersonal violence, sports injuries, and motor vehicle accidents. These fractures may lead to functional and aesthetic complications including diplopia, enophthalmos, infraorbital nerve hypoesthesia, and restriction of extraocular muscle movement. Surgical reconstruction is often required when significant orbital floor disruption leads to orbital volume changes or entrapment of orbital contents. Over the past several decades, multiple surgical approaches have been developed to access the orbital floor, including subciliary, subtarsal, and transconjunctival techniques. Among these, the preseptal transconjunctival approach has gained widespread acceptance due to its ability to provide excellent surgical exposure while minimizing visible scarring and reducing the risk of lower eyelid malposition.
Orbital floor fracture, Transconjunctival approach, Orbital fracture reconstruction
Shady Ghandour Abdelazeem Moawad , Ahmed Mohamed Ali, Hisham Aboalez Ibrahim
UTILISATION OF SKILLED VERSUS UNSKILLED BIRTH ATTENDANCE AMONG RURAL WOMEN IN NIGERIA: A META-ANALYSIS
Utilisation of skilled birth attendance is a key strategy for reducing maternal mortality, yet rural women in Nigeria continue to experience poor access to skilled delivery care. Fragmented evidence has limited understanding of the magnitude and comparative utilisation of skilled and unskilled birth attendance in rural Nigeria. This review with meta-analysis examined the rate of skilled versus unskilled birth attendance utilization among rural women in Nigeria. A systematic search of PubMed, Scopus, and Web of Science was conducted for English-language studies published between January 2021 and 2026. All articles selected employed observational design and all these studies reporting utilisation of skilled or unskilled birth attendance among rural Nigerian women were included. Study quality was assessed using the CASP tool. Pooled prevalence estimates were calculated using meta-analytic techniques and odds ratios were used to compare utilisation patterns. Seven studies involving 69,481 rural women were included. The pooled utilisation of skilled birth attendance was 41%, while unskilled birth attendance was 59%. Rural women were significantly more likely to utilise unskilled than skilled birth attendance (OR = 2.07; 95% CI: 1.17–3.64; p = 0.011). Unskilled birth attendance remains predominant among rural women in Nigeria, highlighting persistent gaps in access to skilled delivery care. This study therefore recommends that, policies should prioritize expansion of accessible and acceptable skilled maternity services in rural communities to improve maternal health outcomes.
Early Functional Outcomes of Intercostal-to-Musculocutaneous Nerve Transfer for Elbow Flexion Restoration After Traumatic Brachial Plexus Injury
Background: Traumatic brachial plexus injury (BPI) in adults frequently results in profound upper limb dysfunction, with loss of elbow flexion representing one of the most disabling deficits. Restoration of active elbow flexion is universally considered the primary reconstructive priority because it enables positioning of the hand in space and facilitates
Functional Outcomes, Intercostal-to-Musculocutaneous Nerve Transfer, Traumatic Brachial Plexus Injury
Alaa Nabil El-Sadek, Mohammad Reda Ahmad, Mohammed Anwer Ezzat
AI-POWERED MACHINE LEARNING ANALYTICS FOR ENHANCING STRATEGIC BUSINESS DECISION-MAKING IN US ENTERPRISES
The obliging processing of them becomes AI/ML analytics, and U.S. businesses are increasingly relying on it to make decisions in a data-rich and competitive environment. While previous research has focused mostly on technical aspects of model performance, there is scant empirical evidence as to how ML analytics can be transformed into interpretable and actionable strategic insights for managers. This gap is addressed in this paper by presenting an AI-driven machine learning analytics framework that is directed towards improving strategic decision-making at the enterprise level. A quantitative empirical design applied through an enterprise workforce analytics data set containing 500 observations and prominent demographic, organizational structural, and behavioral measures. Turnover was chosen as the strategic dependent variable because it pertains to stability in workforce and long-term performance of an organization. Pre-model development data pre-processing and exploratory analysis were carried out. Two machine learning methods were used: logistic regression, chosen as an interpretable baseline model, and a non-linear ensemble model (Random Forest). The model was assessed for performance on the basis of accuracy, precision Recall F1 score, ROC–AUC, and confusion matrix analysis. Furthermore, explainable analytics tools such as feature relevance ranking and partial dependence plots were used to improve interpretability and managerial actionability. The findings demonstrate that in comparison to logistic regression, the Random Forest model performs significantly better with an ROC–AUC value of 0.94 against 0.86. Compensation, organizational tenure, and age joined up in the output as the most contributing factors for predicting attrition, while workload intensity also presented a relevant effect. The explainability analysis detected non-linear threshold effects, making it useful for strategic interpretation beyond prediction performance. Together, the results show that AI-based machine learning analytics can give robust, interpretable, and strategically useful insights. The concept proposal illustrates a promising explanation-based ML as a useful decision-support technology for improved business strategy making of U.S. companies.
Impact of organizational climate on job satisfaction and organizational commitment in selected private Universities in India
-This empirical study aimed to explore the effect of organizational climate on job satisfaction and organizational commitment in a sample one seventynine faculties from universities in India. Descriptive statistics as well as regression analysis were applied to explain the variations in job satisfaction, and organizational climate. Findings showed that organizational climate strongly influences job satisfaction and organizational commitment.
Organizational Climate (OC), Organizational Commitment (OC), Job Satisfaction (JS), Education.
INFLUENCE OF ORGANISATIONAL IMAGE ON STUDENTS’ CHOICES AND DECISIONS TO ENROL IN UNIVERSITIES IN SOUTH-WEST NIGERIA
This study aimed to ascertain the influence of organisational image on students’ choices and decisions in enrolment into federal, state and private universities in the south-west Nigeria. The study used quantitative research method. The population of the study comprised all universities in the south-west Nigeria. Eighteen universities which constituted the sample size were purposively selected on account of reputation and influence. Using Cochran’s (1977) formula for categorical data and the second consequence, a total of 535 respondents were selected for the study and they were chosen through multistage sampling, which included purposive, cluster, stratified, systematic, random. Data were collected through copies of questionnaire. Descriptive data were analysed using descriptive statistics and inferential statistics (Chi-Square test of significance) and statistical programme for social sciences (SPSS). The results indicated that both tangible and intangible aspects of organizational image influence students’ choices and decisions in enrolment into universities in south-west Nigeria though in their varying degrees. The findings revealed that the level of awareness among students was low, with 26.5% of respondents, and in contrast; the level of knowledge about organisational image among students was high, with 81.7% of respondents, who were familiar with the image/reputation of their university; among the elements of organisational image identified, quality of education, academic reputation and institutional prestige were prized high among students; and feedbacks, past/current students were part of valuable communication strategy in enhancing students’ enrolment. The study, thus, recommended that universities should engage and direct their marketing and promotional materials to target audience like secondary schools and their students; leverage on and maintain their organisational image as strategy; focus more and improve on quality of education, academic reputation and prestige among other images that influence students’ choices; and be active on the various channels of communication (like social media, newsletter emailing etc.) and focus on clear and honest communication that accurately represents their strengths.
Copyright (c) 2024 https://creativecommons.org/licenses/by/4.0/deed.en
TWO MODES OF PROJECT-BASED TEACHING METHOD AS A FACTOR ON STUDENTS’ ACHIEVEMENT IN BASIC SCIENCE: IMPLICATIONS FOR MATHEMATICS AND MEASUREMENT EXPERTS
This study examined the efficacy of two modes of project-based teaching methods (grouped and individualized) on students’ academic achievement in Basic Science. The study also examined the influence of gender and the interaction effect of teaching methods and gender on students’ achievement. A quasi-experimental research design was adopted. The population of the study consisted of 2,279 Junior Secondary School II students, from which a sample size of 76 (34 males and 42 females) was drawn and assigned to experimental groups. Data were collected using a validated Basic Science Achievement Test (BSAT). The instrument yielded a reliability coefficient of 0.89 using KR-20 method. Mean and standard deviation were used to answer the research questions, while Analysis of Covariance (ANCOVA) was used to test the hypotheses at 0.05 level of significance. The findings revealed that students taught using the group project-based teaching method achieved significantly higher mean scores than those taught using the individualized project-based teaching method. The results also showed that there was no significant difference in the mean achievement scores of male and female students in Basic Science. Furthermore, the interaction effect of teaching method and gender on students’ achievement was not significant. Based on these findings, the study concluded that the group project-based teaching method is more effective in improving students’ academic achievement in Basic Science and that the method is gender-inclusive. It was therefore recommended that Basic Science teachers should adopt structured group project-based instructional strategies to enhance students’ learning outcomes.
Hippocampal Architecture and Neuroplasticity: Anatomical Foundations of Memory Circuits and Their Susceptibility to Dietary Modulators
Background: The hippocampal formation is a highly specialized medial temporal lobe structure that supports episodic memory, spatial navigation, and context-dependent learning through a tightly organized laminar architecture and stereotyped intrinsic circuitry. Its neuroanatomy is defined by distinct subfields—dentate gyrus, cornu ammonis (CA1–CA4), and the subicular complex—eachcharacterized by unique cytoarchitecture, microcircuit motifs
Hippocampal formation; Dentate gyrus; Cornu ammonis (CA1–CA4); Subiculum; Entorhinal cortex; Perforant path; Fornix; Limbic circuitry; Cytoarchitecture; Neuroplasticity; Pattern separation; Memory consolidation; Vascular supply; Metabolic vulnerability; Dietary modulators; Artificial sweeteners; Oxidative stress; Activity-dependent gene expression.
Amal Al-Shahat Ibrahim, Abdulrahman Alshahat Mohamed Khalil, Dalia Ali Hassan Aiad, Noura Mohamed Qenawy Ahmed
THE EFFICACY AND SAFETY OF LEBRIKIZUMAB PLUS TOPICAL CORTICOSTEDOIDS IN MODERATETO SEVERE ATOPIC DERMATITIS.
Inflammatory and chronic skin conditions such as AD have a serious impact on patients' quality of life. A phase 3 randomised, placebo-controlled trial, ADhere (NCT04250337) examined the efficacy and safety of low-to-mid potency topical corticosteroids (TCSs) that contain IL-13 monoclonal antibody in moderate and severe AD, adolescents, and adults. Combining lebrikizumab and TCS was found to have tremendous effects on skin clearance and itch intensity, sleep disturbances, and quality of life in the trial. There has already been a statistically significant increase in EASI-75 week 4 and IGA (0,1) week 8 responses. Combination therapy was highly compliant and mild or moderate adverse events were reported mainly. In addition, these findings support the use of lebrikizumab and TCS as an effective method of managing moderate and severe AD.
EVALUATION OF TREATMENT EFFICACY AND COST-EFFECTIVENESS FOR WARTS IN PATIENTS WITH ADVANCED MALIGNANCIES
This research paper was to compare the clinical effectiveness and cost-effectiveness of different treatments of warts in 300 patients, considering the complete remission (CR) rates and the cost involved. Human papillomavirus (HPV) is the main cause of warts that can be seen in people of all ages and treated because of its painful and unattractive appearance. The methods of treatment evaluated in the study included four treatments: cryotherapy, topical imiquimod, surgical excision and combinations (cryotherapy and topical imiquimod). Age, gender, performance status, cancer stage (with cancer patients) and previous treatment history were identified as the baseline data. The outcomes indicated that 60 percent of patients attained CR with original warts and 73.3 percent with warts of any kind. The most prevalent modality was cryotherapy (50%), then topical imiquimod (38.9%), and surgical excision (11.1). The recurrence rates of original warts and warts in general were 22.2 and 22.7 respectively. The overall average cost per patient was 3250 that comprised both the direct and indirect cost. The economic model showed that combined therapy was the most affordable of the treatment generated and its cost was 2,450/CR. Cryotherapy and topical imiquimod were both effective and cost-effective and surgical excision was the least cost-effective intervention. These results indicate that cryotherapy and topical imiquimod are more appropriate because of their effectiveness and costs, especially when limited resources are used, and combined therapy may be the most appropriate with respect to the success of therapy and costs.
Patient Knowledge and Disease Activity in Rheumatoid Arthritis: Associations, Determinants, and Implications for Treat-to-Target Care
Background: Rheumatoid arthritis (RA) is a chronic, immune-mediated inflammatory disease characterized by persistent synovitis, progressive joint destruction, and significant functional impairment. Despite major therapeutic advances and the widespread adoption of treatto-target (T2T) strategies, a substantial proportion of patients fail to achieve sustained remission or low disease activity. Growing evidence suggests that patient-related factors, particularly disease-related
Patient Knowledge, Disease Activity, Rheumatoid Arthritis
Fadia Abd Allah Abd Alghany, Lobna Ismaeil Kotb , Eman Abdelsalam Mostafa Abdelkareem, Dina Sameh Mohamed El Rafey
Executive Functions, Challenging Behaviors and Sleep Habits Among Children with Attention Deficit Hyperactivity Disorder
Background: Executive dysfunction is a major factor in the consequences of neurological developmental disorders including attention deficit hyperactivity disorder (ADHD), which causes challenging behavior and decreased social functioning. Additionally, higher sleep problems have been linked to lower executive skills in children with ADHD
ADHD, Challenging behaviours, Executive functions, Sleep Habits
Mai fawzi lotfi zaher , Radwa Ahmed Abdel Razek and Safia Ragab El Sebaie
Diagnostic Performance of Pulse Oximetry Waveform Analysis for Ambulatory Identification of Cardiac Arrhythmias
Background: Cardiac arrhythmias are a major cause of morbidity and mortality worldwide, with atrial fibrillation and other rhythm disturbances frequently remaining undiagnosed due to their intermittent and often asymptomatic nature. Conventional diagnostic strategies, including electrocardiography (ECG) and Holter monitoring, are limited by short monitoring durations, accessibility barriers, and patient adherence issues
Mohamed Salah Abdelbasit, Ahmed Magdi Hamed Mohamed Afify , Mohamad Hossam Eldeen Alshair, Shaimaa Wageeh Mohamed
Early Clinical Outcomes of Arthroscopic Treatment for Femoroacetabular Impingement: A Comprehensive Review
Background: Femoroacetabular impingement (FAI) has emerged as a major etiologic factor in the development of hip pain and early osteoarthritis among young and active individuals. The evolution of hip arthroscopy over the past two decades has provided a minimally invasive alternative to open surgical hip procedures, enabling precise correction of cam and pincer morphology, labral repair, and chondral management with reduced morbidity
Early Clinical Outcomes, Arthroscopic Treatment, Femoroacetabular Impingement
Mohammed Al-Ahmady Abdel-Rahim Ali , Mohammed Othman Mohammed Othman , Walid Ashraf Elnahal , Hany Mohammed Abdel-Fattah Bakr
UGHYT-PLUS: YOLOV11-ENHANCED FEDERATED RL FRAMEWORK FOR ULTRA-PRECISE SPEED ESTIMATION, ANOMALY DETECTION, AND ADAPTIVE TRAFFIC CONTROL IN OCCLUSION-HEAVY URBAN SURVEILLANCE
Urban traffic in India claims over 150,000 lives yearly, with overspeeding and anomalies exacerbating fatalities in occlusion-heavy, low-resolution CCTV environments like Kolkata and Bhopal. Building on the UGHYT framework, this paper introduces UGHYT-Plus—a YOLOv11-enhanced federated reinforcement learning (RL) system fusing self-supervised anomaly detection, evidential speed regression, and adaptive signal control. UGHYT-Plus achieves 96.2% mAP, 1.8 km/h RMSE, and 96% anomaly recall at 25 ms latency on expanded MITS/BDD100K datasets plus custom 75-hour Kolkata CCTV (80% occlusion, 480p, 8-20 FPS). Innovations include contrastive pretraining for incident detection (accidents, emergency vehicles), multi-modal radar fusion for sub-2 km/h precision, and privacy-preserving federated RL optimizing signals to cut congestion by 28%. Outperforming YOLOv10 baselines by 35% in accuracy and 30% in speed, UGHYT-Plus enables scalable 5G-IoT deployment across 100+ feeds on 20W Jetson nodes, paving the way for safer smart cities.
Copyright (c) 2024 Mohit Tiwari, Dr. Vikas Sakalle (Author) https://creativecommons.org/licenses/by/4.0/deed.en
Evaluation of the Toxic Effects of Dichloroacetic Acid on Hippocampus of Adult Male Albino Rats
Background: Dichloroacetic acid (DCAA) is a prevalent disinfection byproducts (DBPs) formed during the chlorination process of drinking water disinfection. Owing to its well-documented toxicological properties, DCAA has attracted substantial scientific attention. Extensive experimental studies in rodent models have demonstrated
Dichloroacetic acid, hippocampus, disinfection byproducts, neurotoxicity.
Basma Taher Megahed Ali , Sarah Elsayed Yousry El Refaey , Shaimaa Ali Abdelrahman , Eman El-Sayed Hassan Khayal , Nourhan Mohammed Hassan
Can Targeting Oxidative Stress and Inflammation with Lycopene Prevent Paclitaxel-Induced Spermatogenic Disruption?
Background: Paclitaxel is a widely used chemotherapeutic agent effective against various solid malignancies, including breast, ovarian, and lung cancers. Despite its therapeutic efficacy, accumulating experimental and clinical evidence indicates that paclitaxel exerts deleterious effects on the male reproductive system. Testicular tissue, characterized by rapid germ cell proliferation and high polyunsaturated fatty acid content, is particularly vulnerable to chemotherapeutic-induced
Paclitaxel; Lycopene; Testicular toxicity; Oxidative stress; Inflammation; Spermatogenesis; Reactive oxygen species; Chemotherapy-induced gonadotoxicity; Antioxidants; NF-κB.
Anogenital Distance as a Biomarker of Androgen Exposure and Female Sexual Function: Clinical Evidence and Mechanistic Links
Background: Anogenital distance (AGD) has emerged as a sexually dimorphic anthropometric measure reflecting prenatal androgen exposure. In females, AGD is increasingly investigated as a noninvasive biomarker of in utero androgenic programming, with potential implications extending into reproductive endocrinology and sexual medicine
Anogenital Distance, Androgen Exposure, Female Sexual Function
Ahmed Ismail Mohamed , Amal Mohamed El-anwar , Nourhan Essam Mohamed Mohamed Mounir , Abdallah Fekry Abdelmaksoud