Nanoemulsion Formulations: A Promising Approach to Anal Fissure Therapy
Keywords:
“Anal fissures, nanoemulsions, drug delivery, diltiazem, glyceryl trinitrate, sphincter hypertonia, ischemiaAbstract
Anal fissures, a common anorectal condition, are characterized by severe pain, bleeding, and delayed healing due to sphincter hypertonia and ischemia. Traditional treatments, including topical ointments, botulinum toxin injections, and surgical interventions, are limited by poor drug penetration, side effects, and high recurrence rates. Nanoemulsions, a novel drug delivery system, offer a promising alternative with their submicron droplet size, enhanced bioavailability, and controlled drug release. These formulations provide superior drug penetration, sustained therapeutic action, and reduced systemic side effects, addressing key challenges in anal fissure management.
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References
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