Nanoparticle delivery system, highly active antiretroviral therapy, and testicular morphology: The role of stereology
DOI:
https://doi.org/10.48047/9f5hzd09Keywords:
nanoparticles (NPs), HAART, antiretroviral therapy, testicular, blood–testis barrierAbstract
One drug delivery method that has a lot of promise for treating HIV infections is the conjugation of
nanoparticles (NPs) with antiretroviral medications. Recent research has brought attention to the
harmful effects of nanoparticles on testicular tissue and their influence on sperm shape, notwithstanding
their potential. When using a nanoparticle drug delivery technology in highly active antiretroviral
therapy (HAART), this review examines the function of stereological techniques in evaluating
testicular morphology. Additionally, a crucial component of this review is the pharmacokinetics and
penetration of NPs with respect to the blood–testis barrier and testicular tissue. Furthermore, different
kinds of NPs used to administer antiretroviral medications in clinical and biological research were
covered in detail.
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