A Unique Strategies for Psoriasis Management: Utilizing Nanoemulsion Based Insitu-Gel Formulation for Topical Administration of Mometasone Furoate
DOI:
https://doi.org/10.48047/cbt7t656Keywords:
Mometasone Furoate, Nanoemulsion, Poloxamer 407, Pseudo-Ternary Phase Diagram, Topical DeliveryAbstract
Mometasone furoate (MF) exhibits low oral bioavailability and can lead to significant adverse effects, rendering oral administration impractical. In order to enhance its solubility and permeability, a nanoemulsion-based in-situ gel was developed for psoriasis treatment. Clove oil, Tween-80 (surfactant), and PEG 400 (co-surfactant) were chosen based on their solubility profiles for MF. A pseudo-tertiary phase diagram was constructed to determine the optimal nanoemulsion formulation. The MF nanoemulsion (MF-NE) was prepared using a drop-by-drop aqueous titration method. The optimized MF-NE demonstrated and thermodynamic stability and was characterized for globule size, zeta potential, refractive index, and viscosity. The final nanoemulsion formulation comprised 2% w/w oil and 20% w/w Smix (surfactant and co-surfactant mixture in 3:1 ratio). This nanoemulsion was incorporated into various concentrations of the gel poloxamer 407. The formulated nanoemulsion-based in-situ gels were evaluated for gelation temperature, pH, drug content, viscosity, in-vitro drug release profiles, and stability. The selected formulation exhibited an enhanced drug release (82.19±1.170%) compared to the marketed gel (53.00±0.818%) preparation. The antioxidant activity of the MF nanoemulsion based in-situ gel was evaluated using the DPPH method. The optimized formulation exhibited non-irritating to the skin in the HET-CAM test. These findings suggest that the nanoemulsion based Insitu gel represents a promising approach to improve the bioavailability and topical delivery of mometasone furoate.
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