Development and Characterization of In Situ Gelling Oromucosal Dexamethasone Formulations: Impact on Drug Delivery
DOI:
https://doi.org/10.48047/a1dfke38Keywords:
Dexamethasone, Oromucosal Delivery, In Situ Gelation, Mucoadhesion, Polymer Formulations, Controlled Release.Abstract
This study focuses on the development and characterization of in situ gelling formulations for oromucosal
delivery of dexamethasone, a corticosteroid commonly used to treat oral mucosal disorders such as ulcers,
gingivitis, and lichen planus. The aim is to improve bioavailability, control drug release, and provide
sustained therapeutic effects. In situ gelling systems undergo gelation upon contact with mucosal surfaces,
allowing for prolonged retention and localized drug delivery. This research investigates the use of different
polymers, including Hydroxypropyl Methylcellulose (HPMC), Carbopol, and Sodium Alginate, to
develop formulations with optimal viscosity, gelation time, and mucoadhesive properties.
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