Investigating the Role of GSDMB rs7216389 Polymorphism in Childhood Asthma

Authors

  • Qudsia Umaira Khan , Afreen Bano , Ismail Mazhar , Aimen Binte Asif , Aan Waseem Author

DOI:

https://doi.org/10.48047/CU/54/03/2720-2742

Keywords:

Childhood asthma, Asthma pathogenesis, GASDERMIN B, GSDMB, rs7216389 variant, genetic polymorphism

Abstract

Objective This study investigates the GASDERMIN B (GSDMB) gene variant rs7216389, exploring the clinical and genetic factors associated with pediatric asthma. It underscores the increasing prevalence of childhood asthma, its distinct characteristics compared to adult-onset asthma, and its significant healthcare burden and mortality, particularly during exacerbations.

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References

Zhou, Y., Li, L., Zhou, D., Yu, Z., Ren, Y., Liao, Y., Yuan, C., Yin, Y., Gu, X., & Cui, Y. (2024). One panel with four single nucleotide polymorphisms for Chinese children with asthma: Integrating public data and whole exome sequencing. Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, 35(6), e14182. https://doi.org/10.1111/pai.14182 2. Voorhies, K., Mohammed, A., Chinthala, L., Kong, S. W., Lee, I. H., Kho, A. T., McGeachie, M., Mandl, K. D., Raby, B., Hayes, M., Davis, R. L., Wu, A. C., & Lutz, S. M. (2024). GSDMB/ORMDL3 Rare/Common Variants Are Associated with Inhaled Corticosteroid Response among Children with Asthma. Genes, 15(4), 420. https://doi.org/10.3390/genes15040420

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Published

2025-02-03

Issue

Vol. 54 No. 3 (2025): Year 2025, Volume 54, Issue 3

Section

Articles

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How to Cite

Investigating the Role of GSDMB rs7216389 Polymorphism in Childhood Asthma (Qudsia Umaira Khan , Afreen Bano , Ismail Mazhar , Aimen Binte Asif , Aan Waseem , Trans.). (2025). Cuestiones De Fisioterapia, 54(3), 2720-2742. https://doi.org/10.48047/CU/54/03/2720-2742