DESIGN, SYNTHESIS, EVALUATION OF BENZOXAZOLE DERIVATIVES FOR ANTI-TUBERCULAR AND ANTI-BACTERIAL ACTIVITY
DOI:
https://doi.org/10.48047/yjgmft37Keywords:
Benzoxazole, M. tuberculosis, Antibacterial and AntimycobacterialAbstract
The antibacterial and antimycobacterial properties of a novel class of benzoxazole compounds
were tested in vitro. The produced benzoxazole compounds were screened for their in vitro
antibacterial activity against Gram-positive bacteria S. aureus and Gram-negative bacteria E. coli
using IR, 1H-NMR, and mass. The antibacterial activity was then tested using a serial dilution
experiment. All medications and antimycobacterial activities against M. tuberculosis are evaluated
for MIC. For antibacterial activity, the serial dilution method (MIC test) was employed, and for
antitubercular activity, the Alamar blue assay test was employed. Compounds 4a, 4c, 4f, and 4i
had strong antibacterial activity against E. coli and S. aureus at 100 and 50 μg/ml, while
Compounds 4c and 4i demonstrated strong antitubercular activity against Mycobacterium
tuberculosis (H-37RV) at 100 and 50 μg/ml.
Downloads
Downloads
Published
Issue
Section
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
You are free to:
- Share — copy and redistribute the material in any medium or format for any purpose, even commercially.
- Adapt — remix, transform, and build upon the material for any purpose, even commercially.
- The licensor cannot revoke these freedoms as long as you follow the license terms.
Under the following terms:
- Attribution — You must give appropriate credit , provide a link to the license, and indicate if changes were made . You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
Notices:
You do not have to comply with the license for elements of the material in the public domain or where your use is permitted by an applicable exception or limitation .
No warranties are given. The license may not give you all of the permissions necessary for your intended use. For example, other rights such as publicity, privacy, or moral rights may limit how you use the material.
