Development and Evaluation of Nanoparticle-Loaded Dissolvable Microneedle Patches for Enhanced Transdermal Drug Delivery of Labetalol: A Novel Therapeutic Strategy
DOI:
https://doi.org/10.48047/54kd3t65Keywords:
Nanoparticle-loaded microneedles, Transdermal drug delivery, Labetalol, Dissolvable microneedle patches, Controlled release, Hypertension treatmentAbstract
The transdermal administration of labetalol, a commonly utilised β-blocker for managing hypertension, is
significantly improved by the innovation of nanoparticle-encapsulated dissolvable microneedle (DMN)
patches. This research delves into the development, analysis, and effectiveness of these DMN patches
aimed at enhancing therapeutic outcomes and patient adherence in the treatment of hypertension.
Integrating nanoparticles within the DMNs significantly boosts the drug's ability to permeate the skin,
resulting in improved bioavailability and a more regulated release when juxtaposed with conventional oral
delivery methods. The microneedles were crafted from polyvinyl alcohol (PVA) and infused with labetalol
nanoparticles produced through the process of solvent evaporation
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