ANTHELMINTIC ACTIVITY OF ETHANOLIC LEAF EXTRACT OF PSEUDERANTHEMUM LATIFOLIUM: AN IN-VITRO STUDY
DOI:
https://doi.org/10.48047/g8bqrd07Keywords:
P. latifolium, Leaves, Anthelmintic potential, Tannins, Saponins, AlkaloidsAbstract
Helminthiasis also known as worm infestation is one of the most prevalent parasitic infestations both in developed and developing countries with about 1.45 million people infested with soil transmitted helminths. The emergence of resistance and toxicity to the conventional anthelmintic drugs and the increasing concern over the presence of drug residues in animal products has led to a renewal of interest in the use of plant based drugs. Therefore, in the current study we aimed for evaluation of anthelmintic activity of ethanolic leaf extract of Pseuderanthemum latifolium. Leaves of P. latifolium was subjected to successive solvent extraction by continuous hot extraction (Soxhlet) with ethanol. The in-vitro anthelmintic activity of ethanolic leaf extract of P. latifolium was determined. Results revealed that the mean time for paralysis (min) was found to be 19.54, 59.49, 48.69, and 29.65 in T1, T2, T3, and T4 respectively. The mean time for death (min) was found to be 23.65, 63.60, 52.80, and 33.76 in T1, T2, T3, and T4 respectively. The results inferred that ethanolic leaf extract of P. latifolium at 50 mg/mL shown anthelmintic activity in terms of time for paralysis and death at par with that of standard anthelmintic drug. In conclusion, ethanolic leaf extract of P. latifolium could be explored in development of natural anthelmintic formulations owing its anthelmintic potential.
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References
Soil-transmitted helminth infections. World Health Organisation. Available from: https://www.who.int/ Newsroom/Factsheets/Detail. Accessed as on January 31, 2025.
Eliminating soil-transmitted helminthiases as a public health problem in children. World Health Organisation.
Available from: https://www.who.int/neglected_diseases/resources. Accessed as on January 31, 2025.
Dhaka R, Verma R, Kumar R, Chayal V, Bhalla K, Singh R, et al. Pattern and determinants of soil-transmitted helminthiasis in a rural area of Haryana: a school
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