Effect of Green-Synthesized Rutin-Loaded MgO Nanoparticles-Infused Scaffold on RUNX2 and ALP Expression
DOI:
https://doi.org/10.48047/zf2v9j68Keywords:
Magnesium Nanoparticles, Rutin, Bone regeneration, Scaffold.Abstract
Introduction: Bone regeneration relies on mesenchymal stem cells (MSCs) to migrate, differentiate, and promote tissue repair. Gene expression regulates this process by transforming genetic information into functional proteins. RUNX2 plays a key role in osteoblast differentiation, while ALP is an early marker of bone mineralization. This study examines the effect of a green-synthesized rutin-loaded MgO nanoparticle-infused scaffold on RUNX2 and ALP expression, assessing its potential for bone regeneration. By evaluating temporal gene expression, we aim to determine the scaffold’s ability to enhance osteogenic differentiation, supporting its use in bone tissue engineering and periodontal regeneration.
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References
Ghanbari E et al., Green Synthesized Magnesium Oxide Nanoparticles Reinforce Osteogenesis Properties of Bacterial Cellulose Scaffolds for Bone Tissue Engineering Applications: An In Vitro Assessment. Cell J. 2023 Jul 25;25(7):483-495.
Hickey DJ et al., Adding MgO nanoparticles to hydroxyapatite-PLLA nanocomposites for improved bone tissue engineering applications. Acta Biomater. 2015; 14: 175-84.
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