INVESTIGATIONS ON THE PHARMACOLOGICAL PROPERTIES OF AJUGA BRACTEOSA EXTRACTS: ANTIOXIDANT ACTIVITY, GLUCOSE METABOLISM, NEUROPROTECTION AND PHYTOCHEMICAL EVALUATION
Keywords:
Antidiabetic, Neuroprotective, In vitro studies, Ajuga bracteosaWall ex Benth., Glucose utilization, DPP-4 inhibition,Abstract
The study evaluated the phytochemical profiles and pharmacological activities of Ajuga bracteosa Wall ex Benth. Leaf extracts, ABME-L (methanolic extract) and ABWE-L (aqueous extract), revealing their potential for therapeutic applications. While alkaloids, glycosides, and saponins were only found in ABME-L, demonstrating methanol's greater extraction effectiveness, phytochemical screening revealed the presence of phenols, carbohydrates, flavonoids, terpenoids, phytosterols, proteins, and tannins in
both extracts. ABME-L exhibited higher total phenolic content (379.74 mg GAE/g) than ABWE-L (288.95 mg GAE/g), suggesting greater antioxidant potential. Glucose utilization and DPP-4 inhibition assays demonstrated the antidiabetic activity of both extracts, with ABME-L showing higher efficacy.
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INVESTIGATIONS ON THE PHARMACOLOGICAL PROPERTIES OF AJUGA BRACTEOSA EXTRACTS: ANTIOXIDANT ACTIVITY, GLUCOSE
METABOLISM, NEUROPROTECTION AND PHYTOCHEMICAL EVALUATION Luan F, Wu Q, Yang Y, Lv H, Liu D, Gan Z, et al. Traditional Uses, Chemical
Constituents, Biological Properties, Clinical Settings, and Toxicities of Abelmoschus manihot L.: A Comprehensive Review. Front Pharmacol. 2020;11:1068.
Pan XX, Tao JH, Jiang S, Zhu Y, Qian DW, Duan JA. Characterization and immunomodulatory activity of polysaccharides from the stems and leaves of
Abelmoschus manihot and a sulfated derivative. Int J Biol Macromol. 2018;107(Pt A):916.
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