Pharmacogenomics in Drug Development: From Discovery to Clinical Trials

Authors

  • Manoj Bhardwaj, Sarvagya Jha, Suman Yadav, Abhyuti Sharma, Pushpendra Kuumar, Diksha Diwakar, Neethu Asokan, Rekha Rani Author

Keywords:

Pharmacogenomics, Drug efficacy, Target Identification, Genetic Markers, Drug Development.

Abstract

Two significant new developments in the medical sciences that affect the efficacy of medication creation and treatment are pharmacogenetics and pharmacogenomics. Even though pharmacogenetic research is being conducted on a big scale these days, its use in medication development needs to begin on a larger scale. With the development of pharmacogenetic research, the two main factors that determine a novel medicinal compound's success—safety and efficacy—have become more predictable. Pharmacogenomic studies, in which the effects of many genes are evaluated by studying the complete genome, are thought to be necessary. 

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References

Surendiran A, Pradhan SC, Adithan C. Role of pharmacogenomics in drug discovery and development. Indian journal of pharmacology. 2008 Jul 1;40(4):137-43.

McCarthy AD, Kennedy JL, Middleton LT. Pharmacogenetics in drug development. Philosophical Transactions of the Royal Society B: Biological Sciences. 2005 Aug 29;360(1460):1579-88.

Lee SY, Nam MH, Kim JS, Kim JW. A case report of a patient carrying CYP2C9* 3/4 genotype with extremely low warfarin dose requirement. Journal of Korean medical science. 2007 Jun;22(3):557.

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Published

2025-01-10

How to Cite

Pharmacogenomics in Drug Development: From Discovery to Clinical Trials (Manoj Bhardwaj, Sarvagya Jha, Suman Yadav, Abhyuti Sharma, Pushpendra Kuumar, Diksha Diwakar, Neethu Asokan, Rekha Rani , Trans.). (2025). Cuestiones De Fisioterapia, 54(2), 1238-1262. https://cuestionesdefisioterapia.com/index.php/es/article/view/834