Formulation and Optimization by Factorial Design of In-situ Ophthalmic gelling systems of Levofloxacin hemihydrates
Keywords:
Levofloxacin, In-situ gelling systems, Carbopol 934p, Sodium alginate.Abstract
Many topically instilled ocular drugs undergo rapid elimination due to tear turnover thereby showing poor absorption. A prolonged precorneal residence time may result in higher absorption and prolonged duration of their therapeutic effect. In-situ gels are retained better in the eye than the conventional ocular dosage forms like eye drops as solutions and suspensions thereby
enhancing bioavailability and duration of therapeutic activity.
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References
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