Synthesis of Novel Indole Derivatives and Assessment of Their Anti-Inflammatory Activity in Experimental Animals
Keywords:
NSAIDs, anti-inflammatory, COX enzymes, heterocyclic compounds, ect.Abstract
Nimesulide and Rofecoxibs are only two examples of the many anti-inflammatory medications with an aryl-ether component that have been demonstrated to cause cell damage and cell death in the liver. We wanted to synthesise novel indole-substituted aryl ethers and evaluate their antiinflammatory activities with minimal side effects, keeping this logic in mind. New aryl ethers that
were substituted with indoles were synthesised.Inflammation is defense mechanism, through which body protects itself from foreign substances. But if human body is not able to deal with it, the secondary option is medications that is NSAIDs but limitations of these drugs are gastrointestinal lesions, nephrotoxicity, etc. To overcome this problem novel molecule has to be synthesised from time to time. Among all the newly synthesised chemicals, 3-methyl Indole derivatives were determined to have the most anti-inflammatory effects based on experimental results. Recent research has shown that 3-methyl Indole derivatives have promising therapeutic potential as an anti-inflammatory medication. The uniqueness of this study lies in its straightforward production process and its promising anti-inflammatory effects in live organisms. The viability of the synthesised chemicals as bioactive candidates with anti-inflammatory activity was further investigated using in-silico investigations. Using the carrageenan-induced rat paw oedema paradigm, the anti-inflammatory efficacy of the synthesised compounds was evaluated.
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Derivatives of Dihydropyrimidinone: Synthesis, Characterization, Molecular Docking and Antimicrobial Activity. Journal of Molecular Structure, 2023, 1291, 136091.
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