ASSESSMENT OF THE RISK OF MALIGNANT TRANSFORMATION IN OSMF CASES USING CUPRIC CHLORIDE- AN OBSERVATIONAL CROSS-SECTIONAL STUDY
Keywords:
Oral submucous fibrosis, blood crystallization, cupric chloride, malignant transformationAbstract
INTRODUCTION:-Oral cancer is a devastating disease prevalent worldwide, often preceded by precancerous disorders like oral submucous fibrosis (OSMF). The variable clinical presentation of OSMF in patients, coupled with non-standardized diagnostic methods and the inherent risk of malignant transformation, underscores the urgent need for accurate diagnostic methods and
effective preventive strategies to combat this debilitating disease. AIM:-To investigate the crystallization patterns in oral squamous cell carcinoma (OSCC), OSMF, and healthy individuals using a minimally invasive and economical crystallization test. METHODOLGY:- A cross sectional serological study was conducted on 114 subjects, divided into three groups of 38 each. A drop of blood was used to perform the test, and the results were statistically analyzed according to the arrangement of crystallization patterns using Chi- square and ANOVA tests. RESULTS:- The eccentric patterns were predominantly found in healthy individuals, while leaf like and hollow glans patterns were more common in OSMF cases. Transverse forms were more frequently observed in OSCC cases. A highly significant difference was found between the study groups. The test was found to be highly sensitive. CONCLUSION:- Crystallization test is a rapid, economical, and minimally invasive laboratory method that can be used as an adjuvant to biopsy for identifying/predicting underlying malignancy in oral premalignant conditions.
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