Importance of collection of drug substance during the peak season and off season: A Review
Keywords:
Alkaloids, on season, off season, LCMS, seasonal variationAbstract
The seasonal variations in alkaloid distribution patterns have been investigated in this study. Seasonal fluctuations play a crucial role in influencing the active principles of medicinal plants. Hence, therapeutic efficacy influenced. Alkaloids are primary compounds, unique to drugs which enhance the main action of the drug. Seasonal variation has direct influence on chemical constituents of the plants. It is analyzed by using Liquid chromatography mass spectrometry (LCMS), High-Performance Liquid Chromatography (HPLC), thin-layer chromatography (TLC), gas chromatography mass spectrometry (GCMS), Co-chromatography, UV spectra etc. Based on these articles LC-MS is predominantly used for the detection of alkaloids. On comprehensive evaluation of 40 articles around 16 articles reported LC-MS and 4 articles HPLC, 4 articles GC-MS, rest of articles reported of other methods. This study concluded that seasonal variation has direct influence in alkaloids of the plants reviewed by collection of various plant alkaloids in off season and on season is recorded.
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References
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