Role of murA and fosB genes in Fosfomycin Resistance in Staphylococcus aureus isolated from Urinary tract infection patients
DOI:
https://doi.org/10.48047/s7xym825Keywords:
Fosfomycin; S. aureus; MurA; FosB; Urinary tract infection.Abstract
Bacterial infection is difficult to treat due to the presence of resistant pathogenic. This study aimed to investigate the phenotypic and molecular aspects of fosfomycin resistance as indicated by the modifying enzymes FosB and MurA in Staphylococcus aureus isolates from patients with Urinary tract infections (UTIs). This study isolated and identified S. aureus isolates from urine specimens using morphological characteristics of the biochemical tests, culture media, and genotypic identification using the 16S rRNA gene. Investigation of antimicrobial susceptibility for eleven different antimicrobials.
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References
Aiezza, N., Antonelli, A., Coppi, M., Di Pilato, V., Giani, T. and Rossolini, G.M., 2023. Up regulation of resident chromosomal fosB gene expression: a novel mechanism of acquired fosfomycin resistance in MRSA. Journal of Antimicrobial Chemotherapy, 78(7), pp.1599-1605.
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