Beyond Mineral Metabolism: Vitamin D Signaling, Microbial Metabolites, and Intestinal Barrier Dysfunction in the Gut–Kidney Axis

Authors

  • Nadine A Raafat, Wesam M. R. Ashour, Hadeel Aiman Elsherbini, Sara Ahmed Mohammed Metwally Author

DOI:

https://doi.org/10.48047/t6t3d883

Keywords:

chronic kidney disease; gut–kidney axis; vitamin D receptor; microbiota; uremic toxins

Abstract

Background: Chronic kidney disease disrupts excretory, endocrine and immune homeostasis, while intestinal dysbiosis can alter microbial metabolite generation and epithelial barrier integrity. Vitamin D signaling has recognized roles in calcium-phosphate regulation and proposed actions in mucosal defense. Objective: To synthesize physiological

Downloads

Download data is not yet available.

References

Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group. KDIGO 2024 clinical practice guideline for the evaluation and management of chronic kidney disease. Kidney Int. 2024;105(4S):S117-S314.

Romagnani P, Agarwal R, Chan JCN, et al. Chronic kidney disease. Nat Rev Dis Primers. 2025;11:8. doi:10.1038/s41572-024-005899.

Downloads

Published

2024-11-20

Issue

Vol. 53 No. 03 (2024): Year 2024, Volume 53, Issue 3

Section

Original

License

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

You are free to:

  1. Share — copy and redistribute the material in any medium or format for any purpose, even commercially.
  2. Adapt — remix, transform, and build upon the material for any purpose, even commercially.
  3. The licensor cannot revoke these freedoms as long as you follow the license terms.

Under the following terms:

  1. Attribution — You must give appropriate credit , provide a link to the license, and indicate if changes were made . You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
  2. No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.

Notices:

You do not have to comply with the license for elements of the material in the public domain or where your use is permitted by an applicable exception or limitation .

No warranties are given. The license may not give you all of the permissions necessary for your intended use. For example, other rights such as publicity, privacy, or moral rights may limit how you use the material.

How to Cite

Beyond Mineral Metabolism: Vitamin D Signaling, Microbial Metabolites, and Intestinal Barrier Dysfunction in the Gut–Kidney Axis (Nadine A Raafat, Wesam M. R. Ashour, Hadeel Aiman Elsherbini, Sara Ahmed Mohammed Metwally , Trans.). (2024). Cuestiones De Fisioterapia, 53(03), 8737-8747. https://doi.org/10.48047/t6t3d883