Genetic and Epigenetic Susceptibility in Biliary Atresia: Developmental Pathways, Molecular Alterations, and Clinical Implications

Authors

  • Ahmed Hamdy Rezk Al Agamy , Hatem Mohammed Hussein , Behery El Sayed Behery , Adel Sherif Ahmed , Samar Ibrahim Ghanem Author

DOI:

https://doi.org/10.48047/as8j9y53

Keywords:

biliary atresia, genetic susceptibility, epigenetics, bile duct development

Abstract

Background: Biliary atresia arises through heterogeneous developmental, genetic and acquired processes, and isolated associations do not yet explain the variable clinical phenotype. Objective: To critically integrate evidence available through 2024 while identifying mechanisms relevant to pediatric hepatology and limitations of current translational studies. Methods:  This narrative review integrates published clinical, genomic and experimental evidence

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References

Jacquemin E, Crestei D, Raynaud N, Hadchouel M. CFC1 gene mutation and biliary atresia with polysplenia syndrome. J Pediatr Gastroenterol Nutr. 2002;34(3):326-9.

Girard M, Panasyuk G. Genetics in biliary atresia. Curr Opin Gastroenterol. 2019;35(2):73-81.

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Published

2024-11-20

Issue

Vol. 53 No. 03 (2024): Year 2024, Volume 53, Issue 3

Section

Original

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How to Cite

Genetic and Epigenetic Susceptibility in Biliary Atresia: Developmental Pathways, Molecular Alterations, and Clinical Implications (Ahmed Hamdy Rezk Al Agamy , Hatem Mohammed Hussein , Behery El Sayed Behery , Adel Sherif Ahmed , Samar Ibrahim Ghanem , Trans.). (2024). Cuestiones De Fisioterapia, 53(03), 8658-8667. https://doi.org/10.48047/as8j9y53