The C-Reactive Protein-to-Albumin Ratio in Chronic Lymphocytic Leukemia: Links to Disease Biology, Treatment Response, and Survival
DOI:
https://doi.org/10.48047/ge7efw20Keywords:
Chronic lymphocytic leukemia; C-reactive protein-to-albumin ratio; systemic inflammation; prognostic biomarker; treatment response; survival.Abstract
Background: Chronic lymphocytic leukemia (CLL) is characterized by marked clinical heterogeneity, ranging from indolent disease requiring prolonged observation to rapidly progressive leukemia associated with treatment resistance and shortened survival. Established prognostic models incorporate clinical stage, molecular abnormalities, immunoglobulin heavy-chain variable-region gene status, serum β2microglobulin, and selected cytogenetic lesions. Nevertheless, several of these assessments are costly
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References
Hallek M. Chronic lymphocytic leukemia: 2025 update on the epidemiology, pathogenesis, diagnosis, and therapy. Am J Hematol. 2025;100(3):450-480.
Shadman M. Diagnosis and treatment of chronic lymphocytic leukemia: a review. JAMA. 2023;329(11):918-932
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