Type 2 Diabetes Mellitus: From Insulin Resistance and β-Cell Failure to Management
DOI:
https://doi.org/10.48047/4rczgz89Keywords:
Type 2 diabetes mellitus, Insulin resistance, β-cell dysfunction, PharmacotherapyAbstract
Background: Type 2 diabetes mellitus (T2DM) is a heterogeneous metabolic disorder in which insulin resistance, progressive β-cell
dysfunction, altered glucagon biology, adipose tissue dysfunction, ectopic lipid deposition, inflammation, and disturbed energy sensing interact over years before overt hyperglycemia appears. The therapeutic landscape has changed markedly, moving from a glucose-centered approach toward simultaneous control of glycemia,
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References
Galicia-Garcia U, Benito-Vicente A, Jebari S, et al. Pathophysiology of type 2 diabetes mellitus. Int J Mol Sci. 2020;21(17):6275.
Abouzid MR, Ali K, Elkhawas I, Elshafei SM. An overview of diabetes mellitus in Egypt and the significance of integrating preventive cardiology in diabetes management. Cureus. 2022;14(7):e27066.
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