Green Tea Polyphenols and Isotretinoin Toxicity: A Critical Review of Hepatic and Male Reproductive Outcomes
DOI:
https://doi.org/10.48047/wt335a31Keywords:
Isotretinoin, green tea polyphenols, hepatotoxicity, male reproductive functionAbstract
Background: Isotretinoin remains an effective treatment for severe acne, but hepatic laboratory abnormalities and experimental testicular injury have stimulated interest in protective interventions. Green tea polyphenols possess biological activities relevant to these effects, although concentrated extracts can themselves produce hepatic injury. Aim: To critically evaluate the pharmacological rationale, hepatic and male reproductive evidence, and translational limitations of green tea polyphenols during isotretinoin
Downloads
References
Reynolds RV, Yeung H, Cheng CE, et al. Guidelines of care for the management of acne vulgaris. J Am Acad Dermatol. 2024;90(5):1006.e1-1006.e30.
Layton A. The use of isotretinoin in acne. Dermatoendocrinology. 2009;1(3):162-169.
Downloads
Published
Issue
Section
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
You are free to:
- Share — copy and redistribute the material in any medium or format for any purpose, even commercially.
- Adapt — remix, transform, and build upon the material for any purpose, even commercially.
- The licensor cannot revoke these freedoms as long as you follow the license terms.
Under the following terms:
- Attribution — You must give appropriate credit , provide a link to the license, and indicate if changes were made . You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
Notices:
You do not have to comply with the license for elements of the material in the public domain or where your use is permitted by an applicable exception or limitation .
No warranties are given. The license may not give you all of the permissions necessary for your intended use. For example, other rights such as publicity, privacy, or moral rights may limit how you use the material.
