Proteolytic Control of Neurotrophin Signaling in Activity-Dependent Brain Plasticity: Relevance to Compulsive-Like Behavior

Authors

  • Nada Alaa Ahmed Moustafa, Akmal Ahmed Hassan Diab, Maha Abdelhamid Fathy, Abeer Abdelmonem Saied Ibrahim Author

DOI:

https://doi.org/10.48047/04zmv912

Keywords:

neuroplasticity, BDNF, proteolytic processing, compulsive behavior

Abstract

Background: Neural plasticity depends not only on the abundance of neurotrophic factors but also on their molecular processing, receptor preference, cellular localization, and temporal pattern of release. Brain-derived neurotrophic factor (BDNF) represents a particularly important example because its precursor, proBDNF, and mature form can engage distinct receptor systems and promote functionally 

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References

Goodman WK, Grice DE, Lapidus KAB, Coffey BJ. Obsessive-compulsive disorder. Psychiatr Clin North Am. 2014;37(3):257-267. doi:10.1016/j.psc.2014.06.004.

Wang M, Xie Y, Qin D. Proteolytic cleavage of proBDNF to mBDNF in neuropsychiatric and neurodegenerative diseases. Brain Res Bull. 2021;166:172-184. doi:10.1016/j.brainresbull.2020.11.005

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Published

2024-11-20

Issue

Vol. 53 No. 03 (2024): Year 2024, Volume 53, Issue 3

Section

Original

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How to Cite

Proteolytic Control of Neurotrophin Signaling in Activity-Dependent Brain Plasticity: Relevance to Compulsive-Like Behavior (Nada Alaa Ahmed Moustafa, Akmal Ahmed Hassan Diab, Maha Abdelhamid Fathy, Abeer Abdelmonem Saied Ibrahim , Trans.). (2024). Cuestiones De Fisioterapia, 53(03), 8353-8359. https://doi.org/10.48047/04zmv912