Vitamin D Deficiency in Multiple Myeloma: Prognostic Significance, Biological Mechanisms, and Clinical Implications

Authors

  • Shimaa Abdelmoneem, Ayman Fathy Arafa, Sohila Ekram Elsaeed, Elsayed Anany Metwally Author

DOI:

https://doi.org/10.48047/wew34947

Keywords:

multiple myeloma; vitamin D deficiency; prognosis; bone marrow microenvironment

Abstract

Background: Multiple myeloma is a clonal plasma cell malignancy characterized by bone marrow infiltration, monoclonal protein production, skeletal destruction, renal impairment, anemia, immune dysfunction, and recurrent relapse. Although advances in proteasome inhibitors, immunomodulatory agents, monoclonal antibodies, autologous stem cell transplantation, bispecific antibodies, and chimeric antigen receptor  T-cell therapy have substantially improved survival, clinical outcomes remain heterogeneous

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References

ajkumar SV, Dimopoulos MA, Palumbo A, et al. International Myeloma Working Group updated criteria for the diagnosis of multiple myeloma. Lancet Oncol. 2014;15(12).

Rajkumar SV. Multiple myeloma: 2022 update on diagnosis, risk stratification, and management. Am J Hematol. 2022;97(8):1086-1107.

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Published

2024-11-20

Issue

Vol. 53 No. 03 (2024): Year 2024, Volume 53, Issue 3

Section

Original

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How to Cite

Vitamin D Deficiency in Multiple Myeloma: Prognostic Significance, Biological Mechanisms, and Clinical Implications (Shimaa Abdelmoneem, Ayman Fathy Arafa, Sohila Ekram Elsaeed, Elsayed Anany Metwally , Trans.). (2024). Cuestiones De Fisioterapia, 53(03), 8121-8129. https://doi.org/10.48047/wew34947