Early-Onset Pancreatic Cancer: A Comprehensive Review of Epidemiology, Etiologic Factors, and Clinical Implications
DOI:
https://doi.org/10.48047/rvary027Keywords:
Early-Onset, Pancreatic Cancer, Clinical ImplicationsAbstract
Background: Pancreatic cancer remains one of the most lethal malignancies worldwide, largely due to its aggressive biology, absence of effective population-based screening strategies, and frequent diagnosis at advanced stages. Although pancreatic ductal adenocarcinoma (PDAC) predominantly affects older individuals, an increasing body of evidence has identified a distinct subgroup of patients diagnosed at a younger age, commonly referred to as early-onset pancreatic cancer (EOPC), typically defined as pancreatic cancer occurring before 50 years of age. Despite representing a minority of pancreatic cancer cases, EOPC has attracted growing clinical interest because of its potentially unique epidemiologic characteristics, differential exposure to risk factors, higherprevalence of hereditary susceptibility, and implications for precision medicine and targeted prevention strategies.
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References
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