Diagnostic Accuracy of Coronary Computed Tomography Angiography for Detecting Ischemic Heart Disease in Adults Aged Over 40 Years with Cardiovascular Risk Factors
DOI:
https://doi.org/10.48047/14s6mf94Keywords:
Coronary computed tomography angiography, Ischemic heart disease, Coronary artery disease, Invasive Coronary Angiography, Fractional flow reserveAbstract
Background: Ischemic heart disease (IHD) remains the main reason for cardiovascular mortality worldwide, accounting for approximately 16% of global mortality. In participants over 40 years of age, the incidence of cardiovascular risk factors significantly elevated the likelihood of coronary artery disease (CAD). The objective was to assess the diagnostic accuracy of CCTA for detecting ischemia-relevant CAD in adults aged >40 years with one or more cardiovascular risk factors.
Methods: This prospective single-center study was done on 150 cases aged >40 years presenting with suspected stable IHD and at least one cardiovascular risk factor. All patients underwent CCTA followed by ICA ± invasive FFR (≤0.80).
Results: Ischemia-relevant CAD was confirmed in 62 patients (41.3%). CCTA established a sensitivity of 96.8%, specificity of 80.5%, positive predictive value (PPV) of 77.2%, negative predictive value (NPV) of 97.7%, and overall diagnostic accuracy of 88.7%.
Conclusions: CCTA provides excellent diagnostic performance with very high negative predictive value, supporting its role as the gold-standard non-invasive diagnostic test for IHD in adults over 40 years with cardiovascular risk factors.
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