Glucocorticoid Sensitivity, Receptor Regulation, and the Development of New-Onset Diabetes After Transplant (NODAT): A Comprehensive Review
DOI:
https://doi.org/10.48047/h38rqq39Keywords:
Glucocorticoid, New-Onset Diabetes After TransplantAbstract
Background: Glucocorticoids remain a cornerstone of immunosuppressive therapy after kidney transplantation, yet their metabolic adverse effects significantly contribute to post-transplant morbidity. Among these, new-onset diabetes after transplant (NODAT) has emerged as a major determinant of long-term graft and patient outcomes. NODAT increases cardiovascular risk, accelerates graft loss, heightens susceptibility to infection, and raises overall mortality.
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References
Davidson J, Wilkinson A, Dantal J, et al. New-onset diabetes after transplantation: 2003 International Consensus Guidelines. Diabetologia. 2003;46(7):1009–1017.
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