Vitamin D₃ and Vitamin K₂ as Modulators of Adaptive Immunity: Insights from Experimental Models of Lymphocyte Dysfunction
DOI:
https://doi.org/10.48047/ja417v06Keywords:
Vitamin D₃, Vitamin K₂ , ImmunityAbstract
Background: Vitamin D₃ and Vitamin K₂ have emerged as key nutrient regulators of immune balance, particularly within the adaptive immune system where B and T lymphocytes play central roles in antigen-specific responses. Experimental and clinical evidence increasingly suggests that Vitamin D₃ modulates lymphocyte maturation, differentiation, cytokine expression, and tolerance, primarily throughbinding of its active metabolite calcitriol to the vitamin D receptor
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References
Baeke F, Takiishi T, Korf H, Gysemans C, Mathieu C. Vitamin D: modulator of the immune system. Curr Opin Pharmacol. 2010;10(4):482-496.
Ohsaki Y, Shirakawa H, Hiwatashi K, et al. Vitamin K suppresses lipopolysaccharide-induced inflammation in the rat liver through inhibition of the NF-κB pathway. J Nutr Biochem. 2010;21(11):1120-1126.
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