Interplay of HER2 Signaling and Barrett’s Esophagus in Patients with GERD: Pathogenesis and Clinical Perspectives
DOI:
https://doi.org/10.48047/aev2am20Keywords:
HER2 Signaling, Barrett’s Esophagus, GERDAbstract
Background: Barrett’s esophagus is a significant complication of chronic gastroesophageal reflux disease (GERD), characterized by the replacement of normal esophageal squamous epithelium with metaplastic columnar epithelium. This metaplasia is associated with an increased risk for the development of esophageal adenocarcinoma, a malignancy with a rising incidence and poor prognosis when diagnosed at advanced stages
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References
Spechler SJ, Souza RF. Barrett’s esophagus. N Engl J Med. 2014;371(9):836-845.
Bang YJ, Van Cutsem E, Feyereislova A, et al. Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial. Lancet. 2010;376(9742):687-697.
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