FORMULATION AND INVITRO EVALUATION OF LEAVES HIBISCUS ROSA-SINENSIS TRANSDERMAL PATCH
DOI:
https://doi.org/10.48047/tanv1521Abstract
This study focuses on the formulation and in-vitro evaluation of transdermal patches using aqueous extracts of Hibiscus rosa-sinensis leaves. The transdermal delivery system, utilizing hydroxypropyl methylcellulose (HPMC) as the primary polymer, is designed to enhance drug absorption through the skin while avoiding first-pass metabolism. The extract was prepared using Soxhlet apparatus, and the patches were fabricated with permeation enhancers like ethanol and Tween-80, along with stabilizers and preservatives. Evaluation parameters, including thickness, weight uniformity, moisture content, and surface pH, were analyzed. The drug release study demonstrated 96.16% release within 11 hours, as determined through UV spectrophotometry at 382 nm. Results indicate that these patches show promise for efficient drug delivery. This work highlights the potential of Hibiscus rosa-sinensis transdermal patches in providing controlled, systemic delivery of bioactive compounds.
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