Potential antioxidant & anti-inflammatory protective effect of melatonin receptor agonist in hypo & hyperthyroid rat model

Authors

  • Radwa M. Alsayed Department of Physiology, Faculty of Medicine -Zagazig University, Egypt Author
  • Yassmen M. El-sayed Department of Pharmacology, Faculty of Medicine -Zagazig University, Egypt, Author
  • Mona K. Alawam Department of Physiology, Faculty of Medicine -Benha University, Egypt Author
  • Areej Omar Ramadhan Abdullah M.B.B.CH, Faculty of Medicine- Sirt University–Lybia Author
  • Eman Abdel Raouf Mohamed Department of Physiology, Faculty of Medicine -Zagazig University , Egypt Author

DOI:

https://doi.org/10.48047/abcd9595

Keywords:

Ramelteon; oxidative stress; thyroid disorders

Abstract

Background: Hormonal instability is linked to inflammation and oxidative stress (OS) through common pathways. Thyroid hormones have been found to play a major part in the antioxidant balance among many hormonal factors, since OS has been linked to both hypothyroidism and hyperthyroidism in humans and animals. A number of research studies have demonstrated the antioxidant, anti-inflammatory, and protective properties of melatonin receptor agonist Ramelteon (RML). Accordingly, the aim of the current study was to examine the potential antioxidant and anti-inflammatory properties of RML on OS induced by thyroid dysfunction (hyperthyroidism, hypothyroidism) in a rat model 

Downloads

Download data is not yet available.

References

- Rashmi Mullur, Yan-Yun Liu, and Gregory A. Brent(2014)Thyroid Hormone Regulation of Metabolism. Physiol Rev. Apr; 94(2): 355–382.

- Zs-Nagy I(2001). On the true role of oxygen free radicals in the living state, aging, and degenerative disorders. Annals of the New York Academy of Sciences. 2001;928:187–199.

Downloads

Published

2023-01-04

Issue

Vol. 52 No. 1 (2023): Year 2023, Volume 52 Issue 1

Section

Articles

License

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

You are free to:

  1. Share — copy and redistribute the material in any medium or format for any purpose, even commercially.
  2. Adapt — remix, transform, and build upon the material for any purpose, even commercially.
  3. The licensor cannot revoke these freedoms as long as you follow the license terms.

Under the following terms:

  1. Attribution — You must give appropriate credit , provide a link to the license, and indicate if changes were made . You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
  2. No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.

Notices:

You do not have to comply with the license for elements of the material in the public domain or where your use is permitted by an applicable exception or limitation .

No warranties are given. The license may not give you all of the permissions necessary for your intended use. For example, other rights such as publicity, privacy, or moral rights may limit how you use the material.

How to Cite

Potential antioxidant & anti-inflammatory protective effect of melatonin receptor agonist in hypo & hyperthyroid rat model (R. . M. Alsayed, Y. . M. El-sayed, M. . K. Alawam, A. O. . Ramadhan Abdullah, & . E. A. Raouf Mohamed , Trans.). (2023). Cuestiones De Fisioterapia, 52(1), 118-130. https://doi.org/10.48047/abcd9595