Revelation of the Antifertility and Antispermatogenic Activity of newly synthesized thioisatin based heterocyclic compounds
DOI:
https://doi.org/10.48047/rsp4xc34Keywords:
Benzothiazolidinone; Fertility test; Sperm motility and count; HematologyAbstract
A variety of novel thioisatin-based heterocyclic compounds were synthesized, characterized, and evaluated for their potential as contraceptive agents by assessing their impact on the reproductive physiology of male albino rats. The results revealed a significant reduction in reproductive organ weight, sperm density, sperm motility, testicular glycogen, testicular protein content, and serum hormone levels, ultimately leading to decreased fertility. Furthermore, changes in antioxidant levels and sperm morphology were observed, accompanied by histopathological evidence of reduced seminiferous tubule diameter and degeneration of interstitial cells.
Downloads
References
Kharkwal G, Fatima I, Kitchlu S, Singh B, Hajela K, Dwivedi A. Anti-implantation effect of 2-[piperidinoethoxyphenyl]-3-[4-hydroxyphenyl]-2H-benzo(b) a potent antiestrogenic agent in rats. Fertility sterity; 2010;https://doi.org/10.1016/j.fertnstert.2010.06.066
Downloads
Published
Issue
Section
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
You are free to:
- Share — copy and redistribute the material in any medium or format for any purpose, even commercially.
- Adapt — remix, transform, and build upon the material for any purpose, even commercially.
- The licensor cannot revoke these freedoms as long as you follow the license terms.
Under the following terms:
- Attribution — You must give appropriate credit , provide a link to the license, and indicate if changes were made . You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
Notices:
You do not have to comply with the license for elements of the material in the public domain or where your use is permitted by an applicable exception or limitation .
No warranties are given. The license may not give you all of the permissions necessary for your intended use. For example, other rights such as publicity, privacy, or moral rights may limit how you use the material.
