Metronidazole Extended-Release Formulation in the Management of Multidrug-Resistant Infections: Efficacy, Mechanisms, and Therapeutic Synergy with Current Treatment Options
DOI:
https://doi.org/10.48047/fq0jjn14Keywords:
Metronidazole, Metronidazole extended-release formulation, Multidrug-Resistant Infections, Alternative therapy, Multidrug Strategy.Abstract
Multidrug-resistant (MDR) infections are becoming more prevalent, which presents serious problems for global healthcare
and calls for creative approaches to treatment as well as a reassessment of current medications. Because of its strong
anaerobic and protozoal action, Metronidazole extended-release formulation has demonstrated promise in treating various
MDR illnesses. The function of Metronidazole extended-release formulation in treating MDR infections is examined in
various studies, with a focus on anaerobic bacteria that are frequently present in soft-tissue, pelvic, and intra-abdominal
infections. The prolonged-release formulation has advantages, such as sustained therapeutic levels and a decreased dosing
frequency, which may improve patient adherence and clinical outcomes, even though it is effective in treating diseases like
bacterial vaginosis, Clostridium difficile infections, etc. This study addresses existing limitations and offers insights into
improving treatment for MDR infections by contrasting Metronidazole extended-release formulation with alternative and
complementary medicines, including glycopeptides, carbapenems, and combination regimens. Although Metronidazole
extended-release formulation is still a useful treatment option for MDR infections, its effectiveness is best complemented
by a multidrug strategy that is customized to the complexity and resistance profile of the illness.
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