Health Implications of Nanoparticles: A Comprehensive Review
DOI:
https://doi.org/10.48047/k0e75w46Keywords:
Nanoparticle, Autoimmune disorders, Physicochemical, Toxicology, HealthAbstract
Nanoparticles (NPs) are extensively utilized in the diagnosis and treatment of numerous human diseases, including autoimmune disorders and cancer. However, the cytotoxic effects of NPs on normal cells and organs remain a significant limiting factor for their clinical application. The diversity of NPs and their physicochemical properties, such as particle size, shape, surface area, dispersity, and protein corona effects, are crucial determinants of their safety and toxicological behavior. Current research focuses on identifying the targets and mechanisms of NP-induced side effects, emphasizing the patterns of NP transport, accumulation, degradation, and elimination in both in vitro and in vivo models. NPs can enter the body through inhalation, dermal contact, and ingestion. Therefore, reliable information on the effects of NPs on various organs is essential to understand their efficacy and health impact. This review consolidates the existing knowledge, aiming to better equip us to address these challenges.
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References
Nanotoxicology and Biocompatibility | Anilocus Center
Ma, X., Tian, Y., Yang, R. et al. Nanotechnology in healthcare, and its safety and environmental risks. J Nanobiotechnol 22, 715 (2024). https://doi.org/10.1186/s12951024-02901-x
Kumar, R., Dutt, S., Tripathi, A.D., Singh, A.K., Chaturvedi, V.K., Singh, S.K. (2024). Navigating Safety and Toxicity Challenges in Nanomedicine: Strategies, Assessment, and Mitigation. In: Gautam, V., Kumar, R., Das Manandhar, K., Kamble, S.C. (eds) Nanomedicine. Nanotechnology in the Life Sciences. Springer, Cham. https://doi.org/10.1007/978-3-031-72467-1_2
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