Curcumin mitigates Monosodium Glutamate induced Oxidative Stress and Hepatotoxicity via alteration of Nrf2 Gene expression in wistar albino rats
DOI:
https://doi.org/10.48047/8n5a0g19Keywords:
Monosodium Glutamate, Curcumin, Hepatotoxicity, Oxidative Stress, Antioxidants, and Nrf2Abstract
Monosodium glutamate (MSG) is the sodium salt of glutamic acid, commonly used as a flavor enhancer. Despite its taste stimulation and improved appetite enhancement, reports indicate that MSG is toxic to human and experimental animals. Low dose MSG on chronic exposure has been shown to induce oxidative stress, and hence finding an effective hepatoprotective agent is very essential. This study evaluates the hepatoprotective and antioxidant effects of Curcumin (CUR) against MSG induced oxidative stress in rats.
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References
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Ataseven, N., Yüzbaşıoğlu, D., Keskin, A. Ç., & Ünal, F. Genotoxicity of monosodium glutamate. Food and Chemical Toxicology, 91(2016), 8.
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