“FORMULATION, CHARACTERIZATION AND IN VITRO EVALUATION OF BETULINIC ACID-LOADED LIPID NANOCARRIERS FOR ENHANCED BIOAVAILABILITY AND SUSTAINED RELEASE IN LUNG CANCER THERAPY”

Authors

  • Namrata Sanjay Mane Head of Department, Nagpur College of Pharmacy, Wanadongri Hingna Road, Nagpur, Maharashtra. Author
  • Pankaj Mohan Pimpalshende Professor cum Principal, Hi-Tech College of Pharmacy Padoli Phata, Nagpur Highway, Morwa, Chandrapur, Maharashtra. 442406 Author
  • Jeevanandham Somasundaram Professor, Department of Pharmaceutics, JKKN College of Pharmacy, (affiliated with The Tamil Nadu Dr.M.G.R. Medical University, Chennai), Kumarapalayam(Tk), Namakkal, Tamil Nadu. 638 183, India Author
  • Muthukumaran Mylasalam Principal cum Professor, School of Pharmacy SBV karaikal, Sri Balaji Vidyapeeth (Deemed to be university), Thiruvetakudi, Karaikal. 609609 Author
  • Indu Mittal Associate Professor, IIMT College of Medical Science (Pharmacy), Ganganagar, Meerut, Uttar Pradesh. 250001 Author
  • V. Saravanan Associate Professor, Department of Aeronautical Engineering, Nehru Institute of Technology, Coimbatore, Tamil Nadu. 641105 Author
  • Renuka D Kadu Assistant Professor, Yeshwantrao Chavan College of Engineering (YCCE), Wanadongri, Hingna Road, Nagpur, Maharshtra. 441110 Author
  • Rutuja Dattatray Chougale Assistant Professor, Department of Pharmaceutics, Bharati Vidyapeeth College of Pharmacy, Shivaji University, Kolhapur. 416013 Author

DOI:

https://doi.org/10.48047/jr94mm57

Keywords:

Betulinic Acid, Lipid nanocarriers, Bioaccessibility improvement, Chemotherapeutic agents, Nanostructured Carriers, Oral drug delivery

Abstract

Betulinic Acid, a bioactive compound with significant anticancer potential, suffers from poor solubility and low bioavailability, limiting its therapeutic efficacy. This study aimed to develop Betulinic Acid-loaded lipid nanocarriers (BALNCs) to enhance drug solubility, bioaccessibility, and controlled release. With particle diameters between 42 and 44 nm, a polydispersity index (PDI) of approximately 0.26, and a zeta potential of approximately 20 mV, the nanocarriers were effectively synthesised and characterised, guaranteeing stability.

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References

Pérez-Herrero E, Fernández-Medarde A. Advanced targeted therapies in cancer: Drug nanocarriers, the future of chemotherapy. European journal of pharmaceutics and biopharmaceutics. 2015;93:52-79.

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Published

2025-02-20

Issue

Vol. 54 No. 4 (2025): Year 2025, Volume 54, Issue 4

Section

Articles

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How to Cite

“FORMULATION, CHARACTERIZATION AND IN VITRO EVALUATION OF BETULINIC ACID-LOADED LIPID NANOCARRIERS FOR ENHANCED BIOAVAILABILITY AND SUSTAINED RELEASE IN LUNG CANCER THERAPY” (N. Sanjay Mane, P. . Mohan Pimpalshende, J. Somasundaram, M. . Mylasalam, I. . Mittal, V. . Saravanan, R. . D Kadu, & R. . Dattatray Chougale , Trans.). (2025). Cuestiones De Fisioterapia, 54(4), 4979-4994. https://doi.org/10.48047/jr94mm57