BIOLOGICAL INVESTIGATION OF A NATURAL POLYSACCHARIDE BLEND: FROM ANTHELMINTIC ACTIVITY IN EARTHWORMS TO CYTOTOXICITY IN BREAST CANCER CELLS
DOI:
https://doi.org/10.48047/ytwkqa80Keywords:
Earthworms, Pherotima posthuma, Albendazole, Cytotoxicity, anthelmintic activity, MTT assayAbstract
The present study evaluates the anthelmintic and cytotoxic activities of a polysaccharide blend (OPASP), composed of Okra polysaccharide (OP) and Angelica sinensis polysaccharide (ASP) in a 1:1
ratio, against Pheretima posthuma earthworms and human cancer cell lines (MCF7, HepG2, and A549).
The anthelmintic activity of OP-ASP was assessed using an in vitro assay, comparing its effects with
Albendazole, a standard anthelmintic drug. The results demonstrated a dose-dependent response, with
OP-ASP showing significant paralysis and death times comparable to Albendazole at higher
concentrations. The MTT test was utilised to assess the cytotoxicity of OP-ASP in MCF7 (breast
cancer), HepG2 (liver cancer), and A549 (lung cancer) cells.
Downloads
Downloads
Published
Issue
Section
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
You are free to:
- Share — copy and redistribute the material in any medium or format for any purpose, even commercially.
- Adapt — remix, transform, and build upon the material for any purpose, even commercially.
- The licensor cannot revoke these freedoms as long as you follow the license terms.
Under the following terms:
- Attribution — You must give appropriate credit , provide a link to the license, and indicate if changes were made . You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
Notices:
You do not have to comply with the license for elements of the material in the public domain or where your use is permitted by an applicable exception or limitation .
No warranties are given. The license may not give you all of the permissions necessary for your intended use. For example, other rights such as publicity, privacy, or moral rights may limit how you use the material.
