In silico screening for seed compounds as potential inhibitors of quorum sensing regulator lasR of Pseudomonas aeruginosa
DOI:
https://doi.org/10.48047/0d1drt86Keywords:
Pseudomonas aeruginosa, Virulence, Docking study, In silico, LasR, Environment, innovative technique, eco friendlyAbstract
Introduction: Quorum sensing (QS) is a mechanism used by many bacteria to synchronize their collective behavior when reaching a sufficient high cell density,QS inhibitors (QSIs) aim at disabling the QS molecular signaling machinery within a bacterial pathogen, effectively rendering cells incapable of sensing the neighboring cell and consequently modifying the regulation of genes As a consequence, QSI modifies the regulation of genes such as biofilm formation, the production of secondary metabolites, and the expression of disease-causing virulence factors. The aim of this study is to identify the QS and biofilm inhibitors through computational analysis of activity compounds against Pseudomonas aeruginosa.
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References
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