CATALYTIC OXIDATION OF ATORVASTATIN BY Th(IV) USING CHLORAMINE-T: A COMPREHENSIVE KINETIC AND MECHANISTIC STUDY

Authors

  • K.M Vidyashree, M.K Arpitha, H.S Sonakshi ,H.P Jayadevappa Author

DOI:

https://doi.org/10.48047/pbn4mr78

Keywords:

Th (IV) Catalysed, Kinetics, Chloramine-T, Atorvastatin, Oxidation, Mechanism

Abstract

The kinetics of the oxidation of atorvastatin (ATV) by chloramine-T (CAT) in a hydrochloric acid solution both uncatalysed and catalysed by Th (IV), have been investigated at 303K. The reaction stoichiometry was established and the oxidation products
were identified. In both catalysed and uncatalysed reactions, the reaction exhibited first order with respect to [CAT], while exhibiting fractional order with regard to [ATV], [HCl], and Catalyst Th (IV). The reaction's rate is not significantly impacted by its products. In both catalysed and uncatalysed processes, the dielectric constant has a marginally unfavourable impact.

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References

R.G. Bakker-Arkema, J. Best, R. Fayyad, T.M. Heinonen, A.D. Marais, J.M. Nawrocki, D.M. Black, Atherosclerosis., 131, 17-23, (1997); https://doi.org/10.1016/S0021-9150(97)06066-8 2) S. Harinder malhotra and L. Karen Goa, Aids Drug Evaluation., 61, 1835-1881, (2001);

https://doi.org/10.2165/00003495-200161120-00012

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Published

2025-02-20

Issue

Vol. 54 No. 4 (2025): Year 2025, Volume 54, Issue 4

Section

Articles

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How to Cite

CATALYTIC OXIDATION OF ATORVASTATIN BY Th(IV) USING CHLORAMINE-T: A COMPREHENSIVE KINETIC AND MECHANISTIC STUDY (K.M Vidyashree, M.K Arpitha, H.S Sonakshi ,H.P Jayadevappa , Trans.). (2025). Cuestiones De Fisioterapia, 54(4), 809-825. https://doi.org/10.48047/pbn4mr78