SYNTHESIS OF MAGNESIUM OXIDE NANOPARTICLES FROM OCIMUM TENUIFLORUM AND ITS TOXICITY ANALYSIS AND ANTIMICROBIAL ACTIVITY
DOI:
https://doi.org/10.48047/jamtrf74Keywords:
.Abstract
Introduction: Ocimum tenuiflorum aka O.sanctum, known as holy basil, belongs to the laminaceae family. It contains oleanolic acid, Ursolic acid, eugenol and various compounds also has various properties such as anti-diabetic, antioxidant, antimicrobial, anticancer, antihelminthic, cardioprotective. Nanotechnology nowadays is expanding greatly in the field of medicine and pharmacy. An important issue that arises is the drug resistance; to overcome this nanotechnology plays a major role wherein nanoparticles reduce the bacterial growth without creating resistance like antibiotics Materials and method: Green extract of the plant was prepared and to which nanoparticle synthesis was done with the help of magnesium nitrate hexahydrate. The anti microbial activity was checked for 2 gram positive bacteria and 2 gram negative bacteria using kirby bauer well diffusion assay. The toxicity was
checked with the help of zebra fish by adding the prepared nanoparticles and with a control group, and their mortality rate was checked. Results and discussion: It was seen that the higher the concentration of the nanoparticles synthesized from the plant, the more the zone of inhibition. The toxicity analysis reveals that the nanoparticles showed reduced toxicity.
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References
Inamuddin, Asiri AM. Applications of Nanotechnology for Green Synthesis. Springer Nature; 2020. 502 p.
Nguyen NYT, Grelling N, Wetteland CL, Rosario R, Liu H. Antimicrobial Activities and Mechanisms of Magnesium Oxide Nanoparticles (nMgO) against
Pathogenic Bacteria, Yeasts, and Biofilms. Sci Rep. 2018 Nov 2;8(1):16260.
Siddhardha B, Dyavaiah M, Kasinathan K. Model Organisms to Study Biological Activities and Toxicity of Nanoparticles. Springer Nature; 2020. 466 p.
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