Predictor biomarkers for cognitive impairment in Temporal Lobe Epilepsy in adults

Authors

  • Ibrahim Mohamed Abdelazeem Hassanein, Azza Elmongui Elmongui, Mervat El Sayed Atta Mashaly, Nehal Tharwat Mohammed El-Sayed, Shimaa Ahmed Elgamal, Wessam Fathi Mohammed Mustafa Author

DOI:

https://doi.org/10.48047/ypdd7r62

Keywords:

HMGB1, temporal lobe epilepsy, cognitive impairment

Abstract

Background: The most frequent cause for focal seizures is temporal lobe epilepsy (TLE). The temporal lobe is primarily responsible for speech, memory, learning, and affective behavior. The previously mentioned functions would be disrupted if the lobe's internal structures were damaged. Aim: To determine cognitive impairment in TLE in adults and to investigate if there was an association between serum levels of HMGB1 and S100B expressions with cognitive impairment in TLE for the possibility of detecting predictive biomarkers for cognitive impairment in TLE.

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References

Vrinda M, Arun S, Srikumar BN, Kutty BM, Shankaranarayana Rao BS. Temporal lobe epilepsy-induced neurodegeneration and cognitive deficits: Implications for aging. Journal of Chemical Neuroanatomy. 2019;95:146-53.

Knierim JJ. The hippocampus. Current Biology. 2015;25(23):R1116-R21.

Riley JD, Franklin DL, Choi V, Kim RC, Binder DK, Cramer SC, et al. Altered white matter integrity in temporal lobe epilepsy: association with cognitive and clinical profiles. Epilepsia. 2010;51(4):536-45.

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Published

2025-01-10

Issue

Vol. 54 No. 2 (2025): Year 2025, Volume 54, Issue 2

Section

Articles

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How to Cite

Predictor biomarkers for cognitive impairment in Temporal Lobe Epilepsy in adults (Ibrahim Mohamed Abdelazeem Hassanein, Azza Elmongui Elmongui, Mervat El Sayed Atta Mashaly, Nehal Tharwat Mohammed El-Sayed, Shimaa Ahmed Elgamal, Wessam Fathi Mohammed Mustafa , Trans.). (2025). Cuestiones De Fisioterapia, 54(2), 2154-2175. https://doi.org/10.48047/ypdd7r62