DEVELOPMENT AND CHARACTERIZATION OF TOLFENAMIC ACID-LOADED SOLID LIPID NANOPARTICLES IN A TOPICAL GEL FOR EFFECTIVE MANAGEMENT OF INFLAMMATORY CONDITIONS
DOI:
https://doi.org/10.48047/CU/54/02/2052-2067Keywords:
Tolfenamic Acid, Solid Lipid Nanoparticles, Sustained Drug Release, Topical Gel Formulation, Permeation Study.Abstract
The objective of the study was to create and assess solid lipid nanoparticles (SLNs) of tolfenamic acid integrated into a topical gel for improved transdermal drug delivery. Using stearic acid and phospholipon 80 as lipid matrices and Pluronic F68 as a stabiliser, SLNs were prepared by high-speed homogenisation and ultrasonication. The optimised SLN formulation (NF-2) showed favourable properties, such as a particle size of 211.51 nm, low polydispersity index (0.221), high zeta potential (-23.6 mV), superior drug loading (0.679%), and entrapment efficiency (73.5%). The in vitro release study showed a sustained drug release profile for NF-2, attaining a cumulative release of 46.06% at 24 hours, in accordance with the Korsmeyer-Peppas model. Topical gels incorporating SLNs were evaluated for physical properties, spreadability, viscosity, and permeation through pig ear skin. The SLN gel exhibited superior permeation, with a steady-state flux of 160.47 µg/cm²/hr over 24 hours, compared to 140.45 µg/cm²/hr for the free drug gel. Fourier-transform infrared (FTIR) examination verified the drugs and excipients' compatibility and stability. The results highlight the potential of SLN-based gels as efficient vehicles for long-term transdermal tolfenamic acid delivery, guaranteeing sustained therapeutic benefit and improved patient adherence.
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References
Aanisah N, Sulistiawati S, Djabir YY, Asri RM, Sumarheni S, Chabib L, et al. Development of Solid Lipid Nanoparticle-Loaded Polymeric Hydrogels Containing Antioxidant and Photoprotective Bioactive Compounds of Safflower (Carthamus tinctorius L.) for Improved Skin Delivery. Langmuir. 2023;39(5):1838-51. doi: 10.1021/acs.langmuir.2c02754.
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