Assess the mmp9 Expression in human Prostate cancer
DOI:
https://doi.org/10.48047/6fdy3y81Keywords:
Prostate cancer, MMP9, Immunohistochemistry, Enzyme-linked assay.Abstract
Prostate cancer is one of the more popular types of cancer, in elderly men, and MMP-9 participates in the progression and invasion of the tumor by their potential to destroy the extracellular matrix of the tissue and then facilitated a migration of cancer cells to form primarily to the secondary tumor. The current study aimed to estimate the MMP9 expression at serum and tissue between controls and patients of prostate cancer, due to the role of proteolysis enzyme such MMP9 in the progression of prostate cancer, to investigate whether there are differences in the levels of circulating immune reactive proteins of MMP-9 complex with Prostate cancer. The method: we used about 100 serum samples by Enzyme-linked assay and 60 samples of embedded tissue by Immunohistochemistry staining (IHCS).Results: The results showed that there is a significant variation between patients and control samples in serum and tissue with a significant value <0.05%.Conclusion: there is an increased expression of MMP9 in the serum and tissue of human prostate cancer.
Downloads
References
Avădanei R, Căruntu I, Amălinei C, Lozneanu L, Balan R, Grigoraş A, Apostol D and Giuşca S 2013. High variability in MMP2/TIMP2 and MMP9/TIMP1 expression in secondary liver tumors. Rom J Morphol Embryol; 54(3):479-85.
Babichenko I, Andriukhin M, Pulbere S and Loktev A 2014. Immuno- histochemical expression of matrix metalloproteinase-9 and inhibitor of matrix metalloproteinase-1 in prostate adenocarcinoma. Int J Clin Exp Pathol. ; 7(12): 9090–9098.
Downloads
Published
Issue
Section
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
You are free to:
- Share — copy and redistribute the material in any medium or format for any purpose, even commercially.
- Adapt — remix, transform, and build upon the material for any purpose, even commercially.
- The licensor cannot revoke these freedoms as long as you follow the license terms.
Under the following terms:
- Attribution — You must give appropriate credit , provide a link to the license, and indicate if changes were made . You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
Notices:
You do not have to comply with the license for elements of the material in the public domain or where your use is permitted by an applicable exception or limitation .
No warranties are given. The license may not give you all of the permissions necessary for your intended use. For example, other rights such as publicity, privacy, or moral rights may limit how you use the material.
