Evidence With Emphasis on Toxicity Profile of Metronomic Capecitabine in Non-Metastatic Triple-Negative Breast Cancer
DOI:
https://doi.org/10.48047/jzehqg50Keywords:
Toxicity Profile, Metronomic Capecitabine, Non-Metastatic Triple-Negative Breast CancerAbstract
Background: Metronomic chemotherapy, defined as the continuous administration of low-dose cytotoxic agents without extended drug-free intervals, has emerged as a promising therapeutic strategy aimed at minimizing toxicity while maintaining antitumor efficacy. Capecitabine, an oral fluoropyrimidine prodrug widely used in breast and gastrointestinal malignancies, has been increasingly investigated in metronomic regimens due to its favorable pharmacokinetic profile and tumor-selective activation. This approach is particularly relevant in patients with limited tolerance to conventional chemotherapy, including those with early-stage triple-negative breast cancer (TNBC), where treatmentrelated toxicity may compromise adherence and outcomes.
Downloads
References
KerbelRS, KamenBA. The anti-angiogenic basis ofmetronomic chemotherapy. NatRevCancer. 2004;4(6):423-436.
Pasquier E, Kavallaris M, André N. Metronomic chemotherapy: new rationale for new directions. Nat Rev Clin Oncol. 2010;7(8):455-465.
André N, Carré M, Pasquier E. Metronomics: towards personalized chemotherapy? Nat Rev Clin Oncol. 2014;11(7):413-431.
Downloads
Published
Issue
Section
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
You are free to:
- Share — copy and redistribute the material in any medium or format for any purpose, even commercially.
- Adapt — remix, transform, and build upon the material for any purpose, even commercially.
- The licensor cannot revoke these freedoms as long as you follow the license terms.
Under the following terms:
- Attribution — You must give appropriate credit , provide a link to the license, and indicate if changes were made . You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
Notices:
You do not have to comply with the license for elements of the material in the public domain or where your use is permitted by an applicable exception or limitation .
No warranties are given. The license may not give you all of the permissions necessary for your intended use. For example, other rights such as publicity, privacy, or moral rights may limit how you use the material.
