Mid-Regional Pro-Adrenomedullin in Spontaneous Bacterial Peritonitis Complicating Decompensated Cirrhosis
DOI:
https://doi.org/10.48047/c548xv15Keywords:
cirrhosis; spontaneous bacterial peritonitis; MR-proADM; adrenomedullin; biomarker; prognosisAbstract
Background: Spontaneous bacterial peritonitis (SBP) remains a major cause of deterioration in decompensated cirrhosis. Ascitic
polymorphonuclear neutrophil counting is indispensable for diagnosis but does not fully represent endothelial injury or circulatory
failure. Mid-regional pro-adrenomedullin (MR-proADM), a stable fragment released with adrenomedullin, reflects inflammatory
and vascular stress
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References
Biggins SW, Angeli P, Garcia-Tsao G, et al. Diagnosis, evaluation, and management of ascites, spontaneous bacterial peritonitis and hepatorenal syndrome: 2021 practice guidance by the American Association for the Study of Liver Diseases. Hepatology. 2021;74(2):1014-1048.
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