Redefining Pediatric Sepsis and Septic Shock: The Role of the Phoenix Criteria
DOI:
https://doi.org/10.48047/n2pbdw08Keywords:
Phoenix Sepsis Score; pediatric sepsis; septicemia; septic shockAbstract
Background: Pediatric sepsis is a life-threatening syndrome caused by a dysregulated host response to infection and remains a major contributor to childhood mortality, organ dysfunction, and long-term disability worldwide. For many years, pediatric sepsis was defined using systemic inflammatory response syndrome–based criteria, although these criteria showed limited specificity, inconsistent bedside application, and inadequate discrimination of children at greatest risk of death. The Phoenix Sepsis Criteria were introduced to provide an evidence-based, globally applicable definition centered on infection-associated organ dysfunction.
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References
Schlapbach LJ, Watson RS, Sorce LR, et al. International consensus criteria for pediatric sepsis and septic shock. JAMA. 2024;331(8):665-674.
Sanchez-Pinto LN, Bennett TD, DeWitt PE, et al. Development and validation of the Phoenix criteria for pediatric sepsis and septic shock. JAMA. 2024;331(8):675-686
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