Correlation of genes (HFE, TF, TFR2) expressions and iron deficiency anemia in children
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https://doi.org/10.48047/z6h0cm76Keywords:
.Abstract
Iron deficiency anemia (IDA) is a prevalent nutritional condition, especially impacting children globally. It arises when there is inadequate iron to satisfy the body's requirements, resulting in diminished hemoglobin levels and compromised oxygen delivery. Iron deficiency anemia in children may lead to developmental delays, cognitive impairments, and heightened vulnerability to infections, making it a critical public health issue that needs greater study. The transferrin gene (TF) encodes the protein transferrin, which is responsible for iron transport in the bloodstream. The transferrin receptor 2 gene (TFR2) encodes a receptor that binds transferrin, facilitating cellular iron uptake. Additionally, the hemochromatosis iron regulator gene (HFE) is involved in regulating iron homeostasis by influencing the body's iron receptors.
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References
Al-Gharban, H. A., and Dhahir, S. H. (2015). Serological diagnosis of persistent infection with Anaplasma marginale bacteria in cattle. The Iraqi Journal of Veterinary Medicine, 39(1), 33-39.
Alessio, D.F., Hentze, M.W., Muckenthaler, M.U. The hemochromatosis proteins HFE, TfR2, and HJV form a membrane-associated protein complex for hepcidin regulation. J Hepatol. 2012; 57(5):1052-1060.
Barton,J.C, Edwards,C.Q., Acton, R.T., HFE gene: Structure, function, mutations, and associated iron abnormalities. Gene. 2015 Dec 15;574(2):179-92.
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