Role of the NR1H4 Genetic Variations and IgG Levels in Immune Thrombocytopenia Development in Children
DOI:
https://doi.org/10.48047/r4vx7235Keywords:
Thrombocytopenic purpura, Human Platelet Factor-4, Pediatric patients, IraqAbstract
Background: The idiopathic thrombocytopenic purpura also known as immune thrombocytopenic purpura (ITP) In children is one of the autoimmune disease classes of unknown etiology, The evaluation of Human Platelet Factor-4 (PF-4) levels in pediatric patients with ITP reveals significant differences when compared to healthy controls and links with NR1H4 gene expression profiles in pediatric patients with ITP provides critical insights into the molecular mechanisms underlying this condition, Spotlight the significant up regulation of NR1H4 with Immunologically and potential utility as a diagnostic biomarker.
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References
Abdaljabbar, H. N., Faraj, S. A., and AL-Rubae, A. M. (2020). Study of Immune Thrombocytopenia (ITP) in Iraqi's children in Wasit Province. EurAsian Journal of BioSciences, 14(2).
Ahmad, A., Imran, M., and Ahsan, H. (2023). Biomarkers as biomedical bioindicators: Approaches and techniques for the detection, analysis, and validation of novel biomarkers of diseases. Pharmaceutics, 15(6), 1630.
Alaa, R. (2024). Prevalence of Immune Thrombocytopenia Purpura in Wasit Province. Wasit Journal for Pure sciences, 3(3), 160-164.
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