AMELIORATIVE EFFECT OF CURCUMIN ON MONOSODIUM GLUTAMATE INDUCED HEPATIC NECROSIS AND STEATOSIS IN WISTAR ALBINO RATS
DOI:
https://doi.org/10.48047/pn2bys73Keywords:
Monosodium Glutamate (MSG), Hepatic Necrosis, Hepatic Steatosis, Curcumin, Silymarin, Hepatoprotective and Anti-Lipidemic Effects.Abstract
Objective: This study aimed to investigate the protective effects of curcumin against low dose
monosodium glutamate (MSG) in chronic use-induced liver damage in rats, focusing on biochemical
markers, lipid profiles, and histopathological changes.
Methods: Six groups of 36 adult male wistar albino rats were grouped as : control, MSG-treated,
MSG+curcumin, MSG+silymarine, curcumin-treated, and silymarin-treated. Serum and liver enzyme
levels, including hepatotoxicity indicators like AST, ALT, ALP, LDH, and GGT, were used to evaluate the
liver function. Hepatic Steatosis indicators are TG, TL,TC, FFA, PL were measured in order to assess the
lipid profile. In order to evaluate the structural damage, liver histology was analyzed.
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